Genomic dynamics of species and mobile genetic elements in a prolonged blaIMP-4-associated carbapenemase outbreak in an Australian hospital

A Kizny Gordon, HTT Phan, SI Lipworth… - Journal of …, 2020 - academic.oup.com
Background Hospital outbreaks of carbapenemase-producing organisms, such as bla IMP-4-
containing organisms, are an increasing threat to patient safety. Objectives To investigate …

Genomic analysis of carbapenemase-producing Enterobacteriaceae in Queensland reveals widespread transmission of bla IMP-4 on an IncHI2 plasmid

LW Roberts, E Catchpoole, AV Jennison… - Microbial …, 2020 - microbiologyresearch.org
Carbapenemase-producing Enterobacteriaceae (CPE) are an increasingly common cause
of healthcare-associated infections and may occasionally be identified in patients without …

Dominance of IMP-4-producing Enterobacter cloacae among carbapenemase-producing Enterobacteriaceae in Australia

HE Sidjabat, N Townell, GR Nimmo… - Antimicrobial agents …, 2015 - Am Soc Microbiol
The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) has been
increasing worldwide. bla IMP has been reported to be the predominant carbapenemase …

Characterization of the Plasmidome Encoding Carbapenemase and Mechanisms for Dissemination of Carbapenem-Resistant Enterobacteriaceae

R Abe, Y Akeda, Y Sugawara, D Takeuchi… - Msystems, 2020 - Am Soc Microbiol
Carbapenem-resistant Enterobacteriaceae (CRE) infections, high in morbidity and mortality,
pose serious clinical challenges due to limited treatment options. A previous CRE …

[HTML][HTML] Wide dissemination of a carbapenemase plasmid among gram-negative bacteria: implications of the variable phenotype

B Espedido, J Iredell, L Thomas… - Journal of clinical …, 2005 - Am Soc Microbiol
Broad-spectrum carbapenem antibiotics are the last bastion of empirical therapy for resistant
gram-negative bacterial infections, and outbreaks of carbapenem-resistant bacterial …

Two carbapenemase-producing Enterobacteriaceae outbreaks detected retrospectively by whole-genome sequencing at an Australian tertiary hospital

A Marmor, K Daveson, D Harley, N Coatsworth… - Infection, disease & …, 2020 - Elsevier
In 2014, two genetically-linked cases of carbapenemase-producing Enterobacteriaceae
(CPE) were detected at the Canberra Hospital (TCH), prompting an investigation and …

[HTML][HTML] Integrating multiple genomic technologies to investigate an outbreak of carbapenemase-producing Enterobacter hormaechei

LW Roberts, PNA Harris, BM Forde… - Nature …, 2020 - nature.com
Carbapenem-resistant Enterobacteriaceae (CRE) represent an urgent threat to human
health. Here we report the application of several complementary whole-genome sequencing …

Hospital-wide outbreaks of carbapenem-resistant Enterobacteriaceae horizontally spread through a clonal plasmid harbouring blaIMP-1 in children's hospitals in …

R Abe, F Oyama, Y Akeda, M Nozaki… - Journal of …, 2021 - academic.oup.com
Carbapenem resistance is primarily conferred by carbapenemases, enzymes that hydrolyse
carbapenems. While KPC, NDM and OXA-48 are the most commonly identified …

Characterization of a blaIMP-4-carrying plasmid from Enterobacter cloacae of swine origin

Y Zhu, W Zhang, S Schwarz, C Wang… - Journal of …, 2019 - academic.oup.com
Objectives To characterize an MDR bla IMP-4-harbouring plasmid from Enterobacter
cloacae EC62 of swine origin in China. Methods Plasmid pIMP-4-EC62 from E. cloacae …

First Report of blaIMP-14 on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131

N Stoesser, AE Sheppard, G Peirano… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
The bla IMP-14 carbapenem resistance gene has largely previously been observed in
Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and …