Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) that results in motor and sensory deficits. Although MS and its animal model …

Abstract The phospholipase A2 (PLA2) superfamily hydrolyzes phospholipids to release free
fatty acids and lysophospholipids, some of which can mediate inflammation and …

Cytosolic phospholipase A2α (cPLA2α) is the rate-limiting enzyme for release of arachidonic
acid, which is converted primarily to prostaglandins via the cyclooxygenase (COX) 1/2 …

Background There is increased interest in the contribution of the innate immune system to
multiple sclerosis (MS), including the activity of acute inflammatory mediators. The purpose …

Experimental autoimmune encephalomyelitis (EAE), a Th1-mediated inflammatory disease
of the central nervous system (CNS), is a model of human multiple sclerosis. Cytosolic …

Abstract Phospholipases A 2 (PLA 2 s) are important enzymes for the metabolism of fatty
acids in membrane phospholipids. Among the three major classes of PLA 2 s in the …

Cytosolic phospholipase A2 (cPLA2) hydrolyzes the arachidonoyl group from the sn-2
position of glycerophospholipids generating arachidonic acid and lysophospholipids. The …

The importance of lipids in cell signaling and tissue physiology is demonstrated by many
CNS pathologies that involve deregulated lipid metabolism. One such critical metabolic …

Background Oxidative stress and inflammation are important factors contributing to the
pathophysiology of numerous neurological disorders, including Alzheimer's disease …

Phospholipases (PLA2s) are a superfamily of enzymes characterized by the ability to
specifically hydrolyze the sn-2 ester bond of phospholipids generating arachidonic acid …