The gastrointestinal tract houses millions of microbes, and thus has evolved several host
defense mechanisms to keep them at bay, and prevent their entry into the host. One such …

Secretory antibodies of the immunoglobulin A (IgA) class form the first line of antigen‐
specific immune protection against inhaled, ingested, and sexually transmitted pathogens …

Abstract Secretory IgA (SIgA) antibodies represent the first line of antigen-specific immune
defense protecting the mucosal surfaces against environmental pathogens and antigens …

The polymeric Ig receptor (pIgR) ensures efficient secretion of polymeric IgA (pIgA) at
mucosal surfaces. On basal to apical transport across epithelial cells, the pIgR extracellular …

Prevention of infections by vaccination remains a compelling goal to improve public health.
Mucosal vaccines would make immunization procedures easier, be better suited for mass …

Abstract Secretory IgA (SIgA) antibodies in the intestinal tract form the first line of antigen-
specific immune defense, preventing access of pathogens as well as commensal microbes …

Antibodies of the secretory IgA (SIgA) class comprise the first line of antigen-specific immune
defense, preventing access of commensal and pathogenic microorganisms and their …

The production of IgA is induced in an antigen-unspecific manner by commensal flora.
These secretory antibodies (SAbs) may bind multiple antigens and are thought to eliminate …

The surface of mucosal sites, such as the intestinal tract, are covered by epithelial cells. To
protect the intestinal environment from invading pathogens and maintain homeostasis, the …

Prevention of infections by vaccination remains a compelling goal to improve public health.
Most infections involve the mucosae, but the development of vaccines against many of these …