Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways

N Sharma, AK Singh, SS Sodhi, JJ Zhang… - Chinese Journal of …, 2017 - Elsevier
Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis (Huang-Qin
or Chinese skullcap) and has been studied thoroughly by many researchers till date for its …

Wogonin and its analogs for the prevention and treatment of cancer: A systematic review

K Banik, E Khatoon, C Harsha, V Rana… - Phytotherapy …, 2022 - Wiley Online Library
The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or
Huang‐Qin, has been used as a traditional medicine for several thousand years. The roots …

Wogonin, as a potent anticancer compound: From chemistry to cellular interactions

HS Tuli, P Rath, A Chauhan… - Experimental …, 2023 - journals.sagepub.com
Chinese native medicine Scutellaria baicalensis Georgi, also referred to as Chinese
skullcap or Huang-Qin, is frequently used to treat cancer, viral infections, and seizures. This …

Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors

X Wu, H Zhang, JMM Salmani, R Fu… - OncoTargets and …, 2016 - Taylor & Francis
As the major bioactive compound of Scutellaria baicalensis that has been approved to be
effective as an anti-inflammatory and antiviral inhibitor in cardiovascular diseases, wogonin …

Toxicological studies of wogonin in experimental animals

Q Qi, J Peng, W Liu, Q You, Y Yang… - … Journal Devoted to …, 2009 - Wiley Online Library
Wogonin, one active ingredient extract from the radix of Scutellaria baicalensis Georgi, is
known to possess a broad spectrum of pharmacological, medicinal and therapeutic …

Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell

M Himeji, T Ohtsuki, H Fukazawa, M Tanaka, S Yazaki… - Cancer Letters, 2007 - Elsevier
Methanol extract from cultured Scutellaria baicalensis cells inhibited the proliferation of
human monocytic leukemia cell line THP-1 and human osteogenic sarcoma cell line HOS …

Potential therapeutic and pharmacological effects of Wogonin: an updated review

DL Huynh, TH Ngau, NH Nguyen, GB Tran… - Molecular Biology …, 2020 - Springer
Flavonoids are members of polyphenolic compounds, which are naturally presented in fruits,
vegetables, and some medicinal plants. Traditionally, the root of Scutellaria baicalensis is …

Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax

M Zhang, LP Liu, Y Chen, X Tian, J Qin, D Wang, Z Li… - Life sciences, 2013 - Elsevier
AIMS: Wogonin is one of the major constituents derived from Scutellaria Baicalensis, which
has been reported to inhibit cell growth and/or induce apoptosis in various cancer cell lines …

Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2

N Lu, Y Gao, Y Ling, Y Chen, Y Yang, HY Gu, Q Qi… - Life sciences, 2008 - Elsevier
Previous studies revealed that wogonin, a naturally occurring monoflavonoid extracted from
Scutellariae radix, possessed anticancer activity both in vitro and in vivo. However, the …

Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K–AKT pathway

KF Huang, YQ Huang, Y Diao - International immunopharmacology, 2012 - Elsevier
Wogonin, one of flavonoid compounds isolated from Chinese herbal plants Scutellaria
baicalensis Georgi, has been recognized as a potent anti-cancer agent acting through …