The NOTCH1/SNAIL1/MEF2C pathway regulates growth and self-renewal in embryonal rhabdomyosarcoma

MS Ignatius, MN Hayes, R Lobbardi, EY Chen… - Cell reports, 2017 - cell.com
Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and
drive continued tumor growth. However, mechanisms regulating TPC self-renewal are …

Hyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells

M De Salvo, L Raimondi, S Vella, L Adesso… - PloS one, 2014 - journals.plos.org
Rhabdomyosarcoma (RMS) is a pediatric myogenic-derived soft tissue sarcoma that
includes two major histopathological subtypes: embryonal and alveolar. The majority of …

MET inhibition sensitizes rhabdomyosarcoma cells to NOTCH signaling suppression

C Perrone, S Pomella, M Cassandri, M Pezzella… - Frontiers in …, 2022 - frontiersin.org
Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma. The Fusion-
Positive (FP) subtype expresses the chimeric protein PAX3-FOXO1 (P3F) while the Fusion …

Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21Cip1 expression and hampers tumour cell …

L Raimondi, R Ciarapica, M De Salvo… - Cell Death & …, 2012 - nature.com
Rhabdomyosarcoma (RMS) is a paediatric soft-tissue sarcoma arising from skeletal muscle
precursors coexpressing markers of proliferation and differentiation. Inducers of myogenic …

A novel notch–YAP circuit drives stemness and tumorigenesis in embryonal rhabdomyosarcoma

KK Slemmons, LES Crose, S Riedel, M Sushnitha… - Molecular Cancer …, 2017 - AACR
Rhabdomyosarcoma (RMS), a cancer characterized by skeletal muscle features, is the most
common soft-tissue sarcoma of childhood. While low-and intermediate-risk groups have …

Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis

BC Belyea, S Naini, RC Bentley, CM Linardic - Clinical Cancer Research, 2011 - AACR
Purpose: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood
and remains refractory to combined-modality therapy in patients with high risk disease. In …

Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma

IM Tenente, MN Hayes, MS Ignatius, K McCarthy… - Elife, 2017 - elifesciences.org
Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory
transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the …

A dysfunctional miR-1-TRPS1-MYOG axis drives ERMS by suppressing terminal myogenic differentiation

SS Hüttner, H Henze, D Elster, P Koch, U Anderer… - Molecular Therapy, 2023 - cell.com
Rhabdomyosarcoma is the most common pediatric soft tissue tumor, comprising two major
subtypes: the PAX3/7-FOXO1 fusion-negative embryonal and the PAX3/7-FOXO1 fusion …

Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma

S Pomella, P Sreenivas, BE Gryder, L Wang… - Nature …, 2021 - nature.com
Rhabdomyosarcoma (RMS) is an aggressive pediatric malignancy of the muscle, that
includes Fusion Positive (FP)-RMS harboring PAX3/7-FOXO1 and Fusion Negative (FN) …

In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma

MS Ignatius, E Chen, NM Elpek, AZ Fuller, IM Tenente… - Cancer cell, 2012 - cell.com
Embryonal rhabdomyosarcoma (ERMS) is an aggressive pediatric sarcoma of muscle. Here,
we show that ERMS-propagating potential is confined to myf5+ cells and can be visualized …