[HTML][HTML] Alzheimer mechanisms and therapeutic strategies

Y Huang, L Mucke - Cell, 2012 - cell.com
There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …

Alzheimer's disease: the challenge of the second century

DM Holtzman, JC Morris, AM Goate - Science translational medicine, 2011 - science.org
Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …

Pathophysiological aspects and therapeutic armamentarium of Alzheimer's disease: recent trends and future development

BP Dave, YB Shah, KG Maheshwari… - Cellular and Molecular …, 2023 - Springer
Alzheimer's disease (AD) is the primary cause of dementia and is characterized by the death
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

DJ Selkoe, D Schenk - Annual review of pharmacology and …, 2003 - annualreviews.org
Degenerative diseases of the brain were long considered among the most obscure and
intractable of human maladies. However, recent advances in understanding their …

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted
neurodegenerative disorder associated with cognition, memory and behavioural …

Insights into the pathophysiology of Alzheimer's disease and potential therapeutic targets: A current perspective

K Rajah Kumaran, S Yunusa, E Perimal… - Journal of …, 2023 - content.iospress.com
The aging population increases steadily because of a healthy lifestyle and medical
advancements in healthcare. However, Alzheimer's disease (AD) is becoming more …

Advances and challenges in the prevention and treatment of Alzheimer's disease

RD Brinton, RS Yamazaki - Pharmaceutical Research, 1998 - Springer
Alzheimer's disease (AD) is the most common cause of dementia and accounts for one-half
to three-fourths of all cases of dementia. In the United States, AD is the leading cause of a …

Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions

A Abeysinghe, R Deshapriya, C Udawatte - Life sciences, 2020 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder and is identified as the most
common cause for dementia. Despite huge global economic burden and the impact on the …

A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease

DK Lahiri, MR Farlow, K Sambamurti… - Current drug …, 2003 - ingentaconnect.com
Alzheimer's disease (AD), a progressive, degenerative disorder of the brain, is believed to
be the most common cause of dementia amongst the elderly. AD is characterized by the …