Epidemiology of acromegaly

IM Holdaway, C Rajasoorya - Pituitary, 1999 - Springer
Acromegaly was defined as a syndrome by Pierre Marie in 1885, but in the form of either
acromegaly or acrogigantism has probably been a disorder of antiquity [1, 2]. It is one of the …

[HTML][HTML] Updates in diagnosis and treatment of acromegaly

R Zahr, M Fleseriu - European endocrinology, 2018 - ncbi.nlm.nih.gov
Acromegaly is a rare disease, caused largely by a growth hormone (GH) pituitary adenoma.
Incidence is higher than previously thought. Due to increased morbidity and mortality, if not …

Acromegaly: the disease, its impact on patients, and managing the burden of long-term treatment

DT Adelman, KJP Liebert, LB Nachtigall… - … journal of general …, 2013 - Taylor & Francis
Acromegaly is a rare disease most often caused by the prolonged secretion of excess
growth hormone from a pituitary adenoma. The disease is associated with multiple …

[引用][C] Clinical review 75: recent advances in pathogenesis, diagnosis, and management of acromegaly

S Melmed, K Ho, A Klibanski, S Reichlin… - The Journal of …, 1995 - academic.oup.com
The CLINICAL consequences of advanced acromegaly are disfigurement, disability, and
shortened life expectancy due to respiratory, metabolic, cardiovascular, and malignant …

Acromegaly

A Colao, LFS Grasso, A Giustina, S Melmed… - Nature Reviews …, 2019 - nature.com
Acromegaly is characterized by increased release of growth hormone and, consequently,
insulin-like growth factor I (IGF1), most often by a pituitary adenoma. Prolonged exposure to …

[HTML][HTML] Acromegaly pathogenesis and treatment

S Melmed - The Journal of clinical investigation, 2009 - Am Soc Clin Investig
Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting
pituitary adenoma and leads to acromegaly—a disorder of disproportionate skeletal, tissue …

Acromegaly

A Ben-Shlomo, S Melmed - Endocrinology and metabolism clinics of North …, 2008 - Elsevier
Acromegaly is a rare disease caused by growth hormone hypersecretion, mostly from a
pituitary adenoma, driving insulin-like growth factor 1 overproduction. Manifestations include …

[HTML][HTML] Acromegaly

P Chanson, S Salenave - Orphanet journal of rare diseases, 2008 - Springer
Acromegaly is an acquired disorder related to excessive production of growth hormone (GH)
and characterized by progressive somatic disfigurement (mainly involving the face and …

Acromegaly

A Colao, B Merola, D Ferone… - The Journal of Clinical …, 1997 - academic.oup.com
Acromegaly is a rare pituitary disorder with an estimated incidence of three to four cases per
million population per year (1). Because it is a chronic and slowly developing disease …

Pathophysiology of acromegaly

S Melmed, GD Braunstein, EVA Horvath… - Endocrine …, 1983 - academic.oup.com
Introduction A CROMEGALY, a spectacular disorder of somatic growth and proportion, has
fascinated endocrinologists for the past century and was the first pituitary disorder to be …