Ropivacaine: an update of its use in regional anaesthesia

KJ McClellan, D Faulds - Drugs, 2000 - Springer
Ropivacaine is a long-acting, enantiomerically pure (S-enantiomer) amide local anaesthetic
with a high pK a and low lipid solubility which blocks nerve fibres involved in pain …

Ropivacaine: a review of its use in regional anaesthesia and acute pain management

D Simpson, MP Curran, V Oldfield, GM Keating - Drugs, 2005 - Springer
Ropivacaine (Naropin®) is the pure S (−)-enantiomer of propivacaine, and is a long-acting
amide local anaesthetic agent, eliciting nerve block via reversible inhibition of sodium ion …

Ropivacaine: a review of its pharmacology and therapeutic use in regional anaesthesia

A Markham, D Faulds - Drugs, 1996 - Springer
Synopsis The enantiomerically pure (S-enantiomer) amide local anaesthetic drug
ropivacaine blocked nerve fibres responsible for transmission of pain (Aδ and fibres) more …

Ropivacaine: a pharmacological review

TG Hansen - Expert review of neurotherapeutics, 2004 - Taylor & Francis
Ropivacaine (Naropin®, AstraZeneca) a new long-acting amide local anaesthetic agent, is a
pure S-enantiomer, with a high pKa and relatively low-lipid solubility. Since its clinical …

Benefit-risk assessment of ropivacaine in the management of postoperative pain

W Zink, BM Graf - Drug safety, 2004 - Springer
Ropivacaine is a long-acting amide-type local anaesthetic, released for clinical use in 1996.
In comparison with bupivacaine, ropivacaine is equally effective for subcutaneous …

Ropivacaine: A review of its pharmacology and clinical use

G Kuthiala, G Chaudhary - Indian journal of anaesthesia, 2011 - journals.lww.com
Ropivacaine is a long-acting amide local anaesthetic agent and first produced as a pure
enantiomer. It produces effects similar to other local anaesthetics via reversible inhibition of …

A double-blind comparison of ropivacaine 0.5%, 0.75%, 1.0% and bupivacaine 0.5%, injected epidurally, in patients undergoing abdominal hysterectomy

BT Finucane, AN Sandler, J Mckenna, D Reid… - Canadian journal of …, 1996 - Springer
Purpose Ropivacaïne is a new long-acting, injectable local anaesthetic currently undergoing
clinical investigation world wide. It is structurally very similar to bupivacaine, but with less …

[PDF][PDF] The place of ropivacaine in anesthesia

R Stienstra - Acta anaesthesiologica Belgica, 2003 - researchgate.net
Ropivacaine has two advantages over bupivacaine. It provides more differential block when
given epidurally, allowing for a better separation between sensory and motor block. This …

A new local anesthetic, ropivacaine: its epidural effects in humans

M Concepcion, GR Arthur, SM Steele… - Anesthesia & …, 1990 - journals.lww.com
The current study was initiated to evaluate the epidural anesthetic properties of 0.5%,
0.75%, and 1.0% ropivacaine, a new local anesthetic agent structurally similar to …

Cardiotoxicity of ropivacaine–a new amide local anaesthetic agent

S Reiz, S Häggmark, G Johansson… - Acta Anaesthesiologica …, 1989 - Wiley Online Library
Anaesthetically equipotent doses of lidocaine, bupivacaine and a new bupivacaine–like
local anaesthetic agent, ropivacaine, were injected into the left anterior descending coronary …