Intestinal mucus forms the first line of defense against bacterial invasion while providing
nutrition to support microbial symbiosis. How the host controls mucus barrier integrity and …

A functional mucus layer is a key requirement for gastrointestinal health as it serves as a
barrier against bacterial invasion and subsequent inflammation. Recent findings suggest …

Mucin-type O-glycans are the primary constituents of mucins that are expressed on various
mucosal sites of the body, especially the bacteria-laden intestinal tract. Mucins are the main …

Over the past two decades, our appreciation of the gut mucus has moved from a static
lubricant to a dynamic and essential component of the gut ecosystem that not only mediates …

The colon mucus layer is organized with an inner colon mucus layer that is impenetrable to
bacteria and an outer mucus layer that is expanded to allow microbiota colonization. A major …

The intestinal tract is inhabited by a tremendous number of microorganisms, termed the gut
microbiota. These microorganisms live in a mutualistic relationship with their host and assist …

MUC2 is the primary component of the mucin barrier that separates the intestinal microbiota
and the intestinal epithelium. This mucous barrier is affected by both luminal/microbial …

Maintaining intestinal health requires clear segregation between epithelial cells and luminal
microbes. The intestinal mucus layer, produced by goblet cells (GCs), is a key element in …

Intestinal cells are covered by mucus. In the small intestine, a single unattached mucus is
present whereas the colon has both an inner attached mucus layer and an outer loose …

The gastrointestinal mucus layer is colonized by a dense community of microbes
catabolizing dietary and host carbohydrates during their expansion in the gut. Alterations in …