[HTML][HTML] Activation of the miR-34a-mediated SIRT1/mTOR signaling pathway by urolithin A attenuates D-galactose-induced brain aging in mice
P Chen, F Chen, J Lei, Q Li, B Zhou - Neurotherapeutics, 2019 - Elsevier
Despite tremendous advances in modern medicine, effective prevention or therapeutic
strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) …
strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) …
[HTML][HTML] Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway
X Kou, X Liu, X Chen, J Li, X Yang, J Fan, Y Yang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The underlying molecular mechanisms for aging-related neurodegenerative diseases such
as Alzheimer's disease (AD) are not fully understood. Currently, growing evidences have …
as Alzheimer's disease (AD) are not fully understood. Currently, growing evidences have …
[HTML][HTML] The gut microbiota metabolite urolithin B improves cognitive deficits by inhibiting Cyt C-mediated apoptosis and promoting the survival of neurons through the …
P Chen, F Chen, J Lei, G Wang, B Zhou - Frontiers in Pharmacology, 2021 - frontiersin.org
Background: Despite considerable advances in pharmacotherapy, more effective
therapeutic interventions for aging-related neurodegenerative disorders (NDs), such as …
therapeutic interventions for aging-related neurodegenerative disorders (NDs), such as …
Swimming attenuates d-galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics
X Kou, J Li, X Liu, J Chang, Q Zhao… - Journal of Applied …, 2017 - journals.physiology.org
microRNAs (miRNAs) have been reported to be involved in many neurodegenerative
diseases. To explore the regulatory role of miR-34a in aging-related diseases such as …
diseases. To explore the regulatory role of miR-34a in aging-related diseases such as …
[HTML][HTML] Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
Z Gong, J Huang, B Xu, Z Ou, L Zhang, X Lin… - Journal of …, 2019 - Springer
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by an abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation …
characterized by an abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation …
Urolithin A‐activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo
Aim Mitochondrial autophagy (mitophagy) clears damaged mitochondria and attenuates
ischemic neuronal injury. Urolithin A (Uro‐A) activates mitophagy in mammal cells and …
ischemic neuronal injury. Urolithin A (Uro‐A) activates mitophagy in mammal cells and …
Induction of autophagy and activation of SIRT‐1 deacetylation mechanisms mediate neuroprotection by the pomegranate metabolite urolithin A in BV2 microglia and …
R Velagapudi, I Lepiarz, A El‐Bakoush… - Molecular Nutrition & …, 2019 - Wiley Online Library
Scope Urolithin A is an anti‐inflammatory and neuroprotective gut‐derived metabolite from
ellagitannins and ellagic acid in pomegranate, berries, and nuts. The roles of SIRT‐1 and …
ellagitannins and ellagic acid in pomegranate, berries, and nuts. The roles of SIRT‐1 and …
Neuroprotective effects of miR-27a against traumatic brain injury via suppressing FoxO3a-mediated neuronal autophagy
L Sun, M Zhao, Y Wang, A Liu, M Lv, Y Li… - Biochemical and …, 2017 - Elsevier
Abstract MicroRNA-27a (miR-27a) has been reported to be a brain-specific miRNA and
aberrantly expressed in the brain suffered from traumatic brain injury (TBI). The present …
aberrantly expressed in the brain suffered from traumatic brain injury (TBI). The present …
[HTML][HTML] MicroRNA-22-3p ameliorates Alzheimer's disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus
P Xia, J Chen, Y Liu, X Cui, C Wang, S Zong… - Journal of …, 2022 - Springer
Background Studies have suggested that many down-regulated miRNAs identified in the
brain tissue or serum of Alzheimer's disease (AD) patients were involved in the formation of …
brain tissue or serum of Alzheimer's disease (AD) patients were involved in the formation of …
Dihydromyricetin attenuates D-galactose-induced brain aging of mice via inhibiting oxidative stress and neuroinflammation
J Qian, X Wang, J Cao, W Zhang, C Lu, X Chen - Neuroscience Letters, 2021 - Elsevier
Aging-related especially brain aging-related diseases are heavy health care burdens
worldwide. Natural products with antioxidant and anti-inflammatory properties have been …
worldwide. Natural products with antioxidant and anti-inflammatory properties have been …