Mammalian mRNAs lose and acquire proteins throughout their life span while undergoing
processing, transport, translation, and decay. How translation affects messenger RNA …

The bulk of cellular proteins derive from the translation of eukaryotic translation initiation
factor (eIF) 4E-bound mRNA. However, recent studies of nonsense-mediated mRNA decay …

In mammals, cap-dependent translation of mRNAs is initiated by two distinct mechanisms:
cap-binding complex (CBC; a heterodimer of CBP80 and 20)-dependent translation (CT) …

Regulation of mRNA translation is a major control point for gene expression and is critical for
life. Of central importance is the complex between cap-bound eukaryotic initiation factor 4E …

During or right after mRNA export via the nuclear pore complex (NPC) in mammalian cells,
mRNAs undergo translation mediated by nuclear cap-binding proteins 80 and 20 …

The mRNA closed-loop, formed through interactions between the cap structure, poly (A) tail,
eIF4E, eIF4G and PAB, features centrally in models of eukaryotic translation initiation …

Initiation of protein synthesis requires both an mRNA and the initiator methionyl (Met)-tRNA
to be bound to the ribosome. Most mRNAs are recruited to the ribosome through recognition …

In the cytoplasm of mammalian cells, either cap-binding proteins 80 and 20 (CBP80/20) or
eukaryotic translation initiation factor (eIF) 4E can direct the initiation of translation. Although …

In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that
is important for mRNA quality control. Following maturation of messenger ribonucleoprotein …

Eukaryotic mRNAs were historically thought to rely exclusively on recognition and binding of
their 5′ cap by initiation factors to effect protein translation. While internal ribosome entry …