Oromucosal Administration of Oxytocin: The Development of 'Oxipops'

D Xu, C Lan, J Kou, S Yao, W Zhao, KM Kendrick - Pharmaceutics, 2024 - mdpi.com
The role of the hypothalamic neuropeptide oxytocin in influencing the brain and behavior
has been the subject of widespread research over the last few decades due, most notably, to …

Opioids and the hormone oxytocin

L Kovatsi, K Nikolaou - Vitamins and Hormones, 2019 - Elsevier
Abstract The neuropeptide Oxytocin (ΟΤ) is involved as a neurohormone, a neurotransmitter,
or a neuromodulator in an extensive range of central and peripheral effects, complex …

From autism to eating disorders and more: the role of oxytocin in neuropsychiatric disorders

A Romano, B Tempesta… - Frontiers in …, 2016 - frontiersin.org
Oxytocin (oxy) is a pituitary neuropeptide hormone synthesized from the paraventricular and
supraoptic nuclei within the hypothalamus. Like other neuropeptides, oxy can modulate a …

The miracle of brain neuropeptides: targeting the brain oxytocin system is a true treatment option in numerous psychiatric disorders including schizophrenia

ID Neumann - Acta Neuropsychiatrica, 2012 - cambridge.org
Dozens of neuropeptides of the brain act in concert to regulate all aspects of behaviour and
physiological functions, including modulatory effects on classical neurotransmitter systems …

Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and
behavior have steadily increased over the last two decades, stimulating considerable …

Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice

ID Neumann, R Maloumby, DI Beiderbeck… - …, 2013 - Elsevier
The possibility to improve socio-emotional behaviors in humans by intranasal administration
of synthetic oxytocin (OXT) attracts increasing attention, but its uptake into the brain has …

Oxytocin as a potential pharmacological tool to combat obesity

PK Olszewski, EE Noble, L Paiva… - Journal of …, 2022 - Wiley Online Library
The neuropeptide oxytocin (OT) has emerged as an important anorexigen in the regulation
of food intake and energy balance. It has been shown that the release of OT and activation …

[PDF][PDF] Oxytocin: An old hormone for new avenues

D Marazziti, A Bani, F Casamassima… - Clinical …, 2006 - researchgate.net
Oxytocin is a nonapeptide synthesized in the paraventricular and supraoptic nuclei of the
hypothalamus. Although other similar substances are present in lower animals, oxytocin has …

The potential of oxytocin as a therapeutic target for psychiatric disorders

S Martinetz, ID Neumann - Expert opinion on therapeutic targets, 2016 - Taylor & Francis
Oxytocin (OXT) is a neuropeptide composed of nine amino acids that is predominantly
expressed in two core regions of the hypothalamus: the paraventricular (PVN) and …

Current findings on the role of oxytocin in the regulation of food intake

MS Spetter, M Hallschmid - Physiology & behavior, 2017 - Elsevier
In the face of the alarming prevalence of obesity and its associated metabolic impairments, it
is of high basic and clinical interest to reach a complete understanding of the central …