Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets

A Mushtaq, P Wu, MM Naseer - Pharmacology & Therapeutics, 2023 - Elsevier
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …

Heterocyclic scaffolds: centrality in anticancer drug development

I Ali, M Nadeem Lone, ZA Al-Othman… - Current drug …, 2015 - ingentaconnect.com
Cancer has been cursed for human beings for long time. Millions people lost their lives due
to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; …

[图书][B] Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I

RK Singh - 2022 - books.google.com
This book provides an update on heterocyclic compounds that serve as key components of
anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted …

Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development

MN Peerzada, E Hamel, R Bai, CT Supuran… - Pharmacology & …, 2021 - Elsevier
Heterocyclic scaffolds are widely utilized for drug design by taking into account the
molecular structure of therapeutic targets that are related to a broad spectrum of ailments …

Heterocyclic anticancer compounds: recent advances and the paradigm shift towards the use of nanomedicine's tool box

P Martins, J Jesus, S Santos, LR Raposo… - Molecules, 2015 - mdpi.com
The majority of heterocycle compounds and typically common heterocycle fragments
present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility …

[PDF][PDF] The importance of heterocyclic compounds in anti-cancer drug design

S Pearce - Drug Discovery, 2017 - ddw-online.com
Heterocycles are key structural components of many of the anti-cancer drugs available on
the market today. Indeed, of the novel molecular anti-cancer agents approved by the FDA …

Heterocyclic Molecular Targeted Drugs and Nanomedicines for Cancer: Recent Advances and Challenges

J Liu, T Chao, Y Liu, C Gong, Y Zhang, H Xiong - Pharmaceutics, 2023 - mdpi.com
Cancer is a top global public health concern. At present, molecular targeted therapy has
emerged as one of the main therapies for cancer, with high efficacy and safety. The medical …

Heterocyclic Compounds: Importance in Anticancer Drug Discovery

N Kumar, N Goel - Anti-Cancer Agents in Medicinal Chemistry …, 2022 - ingentaconnect.com
Cancer, a crucial global health problem, is characterized by abnormal cell division and
uncontrolled growth. According to WHO, cancer is the second leading cause of global …

Novel anticancer agents and targets: recent advances and future perspectives

KP Barot, S Nikolova, I Ivanov… - Mini Reviews in …, 2013 - ingentaconnect.com
An urgent need for the discovery of novel anticancer agents is required for the long term
therapy of cancer. Large number of novel bio-active and potential anticancer agents are …

[PDF][PDF] FDA-approved heterocyclic molecules for cancer treatment: Synthesis, dosage, mechanism of action and their adverse effect

M Hossain, I Habib, K Singha, A Kumar - Heliyon, 2024 - cell.com
As the incorporation of heterocycles increases the physical characteristics and biological
activity of pharmacological molecules, heterocyclic scaffolds are commonly discovered as …