Super-fast in situ formation of hydrogels based on multi-arm functional polyethylene glycols as endotamponade substitutes

R Ran, W Shi, Y Gao, T Wang, X Ren, Y Chen… - Journal of Materials …, 2021 - pubs.rsc.org
Polymer-based hydrogels used in the vitreous cavity could lead to an unsatisfactory gel-
forming state, uncontrollable swelling, and potential cytotoxicity. Their application can …

In-situ forming PEG-engineering hydrogels with anti-fouling characteristics as an artificial vitreous body

T Wang, J Deng, R Ran, W Shi, Y Gao, X Ren… - Chemical Engineering …, 2022 - Elsevier
Endotamponade is in huge demand for vitrectomy, while current vitreous substitutes exhibit
instability and foreign body reactions that impede long-term implantation. Herein, we report …

Polymeric hydrogel as a vitreous substitute: current research, challenges, and future directions

T Wang, R Ran, Y Ma, M Zhang - Biomedical Materials, 2021 - iopscience.iop.org
Vitreoretinal surgery is an essential approach to treat proliferative diabetic vitreopathy,
retinal detachment, retinal tear, ocular trauma, and macular holes. The removal of the …

Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material

Y Tao, X Tong, Y Zhang, J Lai, Y Huang, YR Jiang… - Acta biomaterialia, 2013 - Elsevier
Currently there is no material that can be used as a long-term vitreous substitute, and this
remains an unmet clinical need in ophthalmology. In this study, we developed an injectable …

Fast-forming hydrogel with ultralow polymeric content as an artificial vitreous body

K Hayashi, F Okamoto, S Hoshi, T Katashima… - Nature Biomedical …, 2017 - nature.com
Degradation-induced swelling in implanted hydrogels can cause severe adverse reactions
in surrounding tissues. Here, we report a new class of hydrogel with extremely low swelling …

High molecular weight hyper-branched PCL-based thermogelling vitreous endotamponades

Q Lin, Z Liu, DSL Wong, CC Lim, CK Liu, L Guo… - Biomaterials, 2022 - Elsevier
Vitreous endotamponades play essential roles in facilitating retina recovery following
vitreoretinal surgery, yet existing clinically standards are suboptimal as they can cause …

In situ forming hydrogels: a Thermo‐Responsive polyelectrolyte as promising liquid artificial vitreous body replacement

F Strotmann, E Bezdushna, H Ritter… - Advanced Engineering …, 2011 - Wiley Online Library
The use of fully synthetic polymers as a liquid artificial vitreous body replacement (LAVR)
was already considered, but yet none of these polymers have proven to be successful in …

Polymeric hydrogels as a vitreous replacement strategy in the eye

Q Lin, JYC Lim, K Xue, X Su, XJ Loh - Biomaterials, 2021 - Elsevier
Vitreous endo-tamponades are commonly used in the treatment of retinal detachments and
tears. They function by providing a tamponading force to support the retina after retina …

Poly (ethylene glycol) based hydrogels for intraocular applications

F Brandl, M Henke, S Rothschenk… - Advanced …, 2007 - Wiley Online Library
Hydrogels are attractive materials for biomedical applications due to their versatility and
excellent biocompatibility. In this study, we report the preparation of poly (ethylene …

Bioinspired fibrillary hydrogel with controlled swelling behavior: applicability as an artificial vitreous

S Santhanam, YB Shui, J Struckhoff… - ACS applied bio …, 2018 - ACS Publications
The vitreous humor of the eye is mainly composed of fibrillary collagen and semiflexible
hyaluronic acid (HA). To mimic this macromolecular composition of the vitreous, we …