Super-fast in situ formation of hydrogels based on multi-arm functional polyethylene glycols as endotamponade substitutes
R Ran, W Shi, Y Gao, T Wang, X Ren, Y Chen… - Journal of Materials …, 2021 - pubs.rsc.org
Polymer-based hydrogels used in the vitreous cavity could lead to an unsatisfactory gel-
forming state, uncontrollable swelling, and potential cytotoxicity. Their application can …
forming state, uncontrollable swelling, and potential cytotoxicity. Their application can …
In-situ forming PEG-engineering hydrogels with anti-fouling characteristics as an artificial vitreous body
T Wang, J Deng, R Ran, W Shi, Y Gao, X Ren… - Chemical Engineering …, 2022 - Elsevier
Endotamponade is in huge demand for vitrectomy, while current vitreous substitutes exhibit
instability and foreign body reactions that impede long-term implantation. Herein, we report …
instability and foreign body reactions that impede long-term implantation. Herein, we report …
Polymeric hydrogel as a vitreous substitute: current research, challenges, and future directions
T Wang, R Ran, Y Ma, M Zhang - Biomedical Materials, 2021 - iopscience.iop.org
Vitreoretinal surgery is an essential approach to treat proliferative diabetic vitreopathy,
retinal detachment, retinal tear, ocular trauma, and macular holes. The removal of the …
retinal detachment, retinal tear, ocular trauma, and macular holes. The removal of the …
Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material
Currently there is no material that can be used as a long-term vitreous substitute, and this
remains an unmet clinical need in ophthalmology. In this study, we developed an injectable …
remains an unmet clinical need in ophthalmology. In this study, we developed an injectable …
Fast-forming hydrogel with ultralow polymeric content as an artificial vitreous body
Degradation-induced swelling in implanted hydrogels can cause severe adverse reactions
in surrounding tissues. Here, we report a new class of hydrogel with extremely low swelling …
in surrounding tissues. Here, we report a new class of hydrogel with extremely low swelling …
High molecular weight hyper-branched PCL-based thermogelling vitreous endotamponades
Vitreous endotamponades play essential roles in facilitating retina recovery following
vitreoretinal surgery, yet existing clinically standards are suboptimal as they can cause …
vitreoretinal surgery, yet existing clinically standards are suboptimal as they can cause …
In situ forming hydrogels: a Thermo‐Responsive polyelectrolyte as promising liquid artificial vitreous body replacement
F Strotmann, E Bezdushna, H Ritter… - Advanced Engineering …, 2011 - Wiley Online Library
The use of fully synthetic polymers as a liquid artificial vitreous body replacement (LAVR)
was already considered, but yet none of these polymers have proven to be successful in …
was already considered, but yet none of these polymers have proven to be successful in …
Polymeric hydrogels as a vitreous replacement strategy in the eye
Vitreous endo-tamponades are commonly used in the treatment of retinal detachments and
tears. They function by providing a tamponading force to support the retina after retina …
tears. They function by providing a tamponading force to support the retina after retina …
Poly (ethylene glycol) based hydrogels for intraocular applications
F Brandl, M Henke, S Rothschenk… - Advanced …, 2007 - Wiley Online Library
Hydrogels are attractive materials for biomedical applications due to their versatility and
excellent biocompatibility. In this study, we report the preparation of poly (ethylene …
excellent biocompatibility. In this study, we report the preparation of poly (ethylene …
Bioinspired fibrillary hydrogel with controlled swelling behavior: applicability as an artificial vitreous
S Santhanam, YB Shui, J Struckhoff… - ACS applied bio …, 2018 - ACS Publications
The vitreous humor of the eye is mainly composed of fibrillary collagen and semiflexible
hyaluronic acid (HA). To mimic this macromolecular composition of the vitreous, we …
hyaluronic acid (HA). To mimic this macromolecular composition of the vitreous, we …