The female ovary contains a finite number of oocytes, and their release at ovulation
becomes sporadic and disordered with aging and with obesity, leading to loss of fertility …

Ovarian fibrosis is a pathological condition associated with aging and is responsible for a
variety of ovarian dysfunctions. Given the known contributions of tissue fibrosis to …

Under normal physiological conditions, tissue remodeling in response to injury leads to
tissue regeneration without permanent damage. However, if homeostasis between synthesis …

Aging is associated with reduced tissue remodeling efficiency and increased fibrosis,
characterized by excess collagen accumulation and altered matrix degradation. Ovulation …

Decline in ovarian reserve with advancing age is associated with reduced fertility and the
emergence of metabolic disturbances, osteoporosis, and neurodegeneration. Recent …

Reproductive aging is characterized by a marked decline in oocyte quality that contributes to
infertility, miscarriages, and birth defects. This decline is multifactorial, and the underlying …

In mammals, ovarian function is dependent on the primordial follicle pool and the rate of
primordial follicle activation determines a female's reproductive lifespan. Ovarian ageing is …

The fertility of women declines sharply after age 35 and is essentially lost upon menopause
at age 51. The ovary plays an important part in aging-associated changes in women's …

Ovarian aging in women correlates with the progressive loss of both the number and quality
of oocytes. When these processes occur early or are accelerated, their clinical correlates are …

In a society where women often want successful careers and equal opportunities to men, the
early nature of ovarian aging often forces women to make difficult life choices between …