Background: Bromodomains are a structurally conserved epigenetic reader domain that
bind to acetylated lysine residues in both histone and non-histone proteins. Bromodomain …

BET proteins are epigenetic readers whose deregulation results in cancer and inflammation.
We show that BET proteins (BRD2, BRD3, BRD4 and BRDT) are globally similar with subtle …

Background: Protein-protein interaction networks are of great importance for understanding
the complexity of biological processes and diseases, including cancer. However, detecting …

Bromodomains (BDs) regulate gene expression by recognizing protein motifs containing
acetyllysine. Although originally characterized as histone-binding proteins, it has since …

Purpose Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide.
The occurrence and development of HCC are closely related to epigenetic modifications …

Epigenetic mechanisms involving DNA methylation and chromatin modifications have
emerged as critical facilitators of cancer heterogeneity, substantially affecting cancer …

Compared to other placental mammals, humans have unique thinking and cognitive abilities
because of their developed cerebral cortex composed of billions of neurons and synaptic …

Phosphoprotein-binding domains (PPBDs) mediate many important cellular and molecular
processes. Ten PPBDs have been known to exist in the human proteome, namely, 14-3-3 …

Background Bromodomain is an evolutionally conserved domain that is found in proteins
strongly implicated in signal-dependent transcriptional regulation. Genetic alterations of …

Motivation: With the growing availability of high-throughput protein–protein interaction (PPI)
data, it has become possible to consider how a protein's local or global network …