Background Antimicrobial treatment in critically ill patients can either be started as soon as
infection is suspected or after objective data confirm an infection. We postulated that …

OBJECTIVES: Best practice guidelines and quality metrics recommend immediate antibiotic
treatment for all patients with suspected sepsis. However, little is known about how many …

Objective To characterize empiric antibiotic use in patients with suspected nosocomial ICU-
acquired infections (NI), and determine the impact of prolonged therapy in the absence of …

Objective: To determine the influence of microbiologically confirmed infection on hospital
mortality among patients requiring intensive care for> 48 h. Design: Prospective cohort …

Objectives To determine the attributable mortality and excess length of stay (LOS)
associated with the use of inadequate empirical antimicrobial therapy in patients with sepsis …

Objective: To assess the timing of appropriate antibiotic therapy as a determinant of
postinfection hospital and ICU lengths of stay in patients with sepsis. Design: Single-center …

Background Most intensive care unit (ICU) patients receive broad-spectrum antibiotics.
While lifesaving in some, in others these treatments may be unnecessary and place patients …

Study objective To evaluate the relationship between inadequate antimicrobial treatment of
infections (both community-acquired and nosocomial infections) and hospital mortality for …

Importance Infection is frequent among patients in the intensive care unit (ICU).
Contemporary information about the types of infections, causative pathogens, and outcomes …

Objective: In this study, clinical practice guidelines were developed by a multidisciplinary
team for patients with infections admitted to a surgical intensive care unit (ICU). Design: A 51 …