[HTML][HTML] Revisiting Richter transformation in the era of novel CLL agents

A Petrackova, P Turcsanyi, T Papajik, E Kriegova - Blood Reviews, 2021 - Elsevier
Richter transformation (RT) is the development of aggressive lymphoma–most frequently
diffuse large B-cell lymphoma (DLBCL) and rarely Hodgkin lymphoma (HL)–arising on the …

Richter transformation—is there light at the end of this tunnel?

TA Eyre - Hematology, 2023 - ashpublications.org
Richter transformation (RT) represents an uncommon (2% to 10%) but feared complication
of chronic lymphocytic leukemia (CLL). The disease is characterized by rapid disease …

Richter transformation of CLL

N Jain, MJ Keating - Expert review of hematology, 2016 - Taylor & Francis
Introduction: Richter transformation (RT) represents an aggressive transformation of chronic
lymphocytic leukemia (CLL), most commonly into diffuse large B cell lymphoma (DLBCL). It …

Richter transformation in the era of novel agents

W Ding - Hematology 2014, the American Society of …, 2018 - ashpublications.org
Recent approvals of several oral targeted agents have revolutionized chronic lymphocytic
leukemia (CLL) therapy. However, CLL patients continue to progress; particularly, 4% to …

[HTML][HTML] Richter transformation in chronic lymphocytic leukemia: update in the era of novel agents

T Tadmor, I Levy - Cancers, 2021 - mdpi.com
Simple Summary Richter transformation is a significant and devastating complication of
chronic lymphocytic leukemia. While its pathogenesis has been well-studied in terms of …

Practical management of Richter transformation in 2023 and beyond

CE Ryan, MS Davids - … Society of Clinical Oncology Educational Book, 2023 - ascopubs.org
While the past decade has witnessed unprecedented progress for patients with chronic
lymphocytic leukemia (CLL), outcomes for patients with Richter transformation (RT) remain …

Patient characteristics that predict Richter's transformation in patients with chronic lymphocytic leukemia treated with ibrutinib

AS Kittai, Y Huang, KA Beckwith… - American Journal of …, 2023 - Wiley Online Library
Chronic lymphocytic leukemia (CLL) transformation to aggressive lymphoma, known as
Richter's Transformation (RT), has a dismal prognosis. There are limited data evaluating risk …

[HTML][HTML] Acalabrutinib monotherapy in patients with Richter transformation from the phase 1/2 ACE-CL-001 clinical study

P Hillmen, A Schuh, TA Eyre, JM Pagel, JR Brown… - Blood, 2016 - Elsevier
Background: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the
Western world, with an annual incidence of 4.7 per 100,000 adults. Approximately 5% to …

Richter transformation in chronic lymphocytic leukemia (CLL)—a pooled analysis of German CLL Study Group (GCLLSG) front line treatment trials

O Al-Sawaf, S Robrecht, J Bahlo, AM Fink, P Cramer… - Leukemia, 2021 - nature.com
Richter transformation (RT) is defined as development of aggressive lymphoma in patients
(pts) with CLL. The incidence rates of RT among pts with CLL range from 2 to 10%. The aim …

[HTML][HTML] Clinical characteristics and outcomes of Richter transformation: experience of 204 patients from a single center

Y Wang, MA Tschautscher, KG Rabe, TG Call… - …, 2020 - ncbi.nlm.nih.gov
The natural history, prognostication and optimal treatment of Richter transformation
developed from chronic lymphocytic leukemia (CLL) are not well defined. We report the …