Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

M Agrawal, S Saraf, S Saraf, SG Antimisiaris… - Journal of controlled …, 2018 - Elsevier
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …

Nose-to-brain drug delivery approach: A key to easily accessing the brain for the treatment of Alzheimer's disease

A Alexander, S Saraf - Neural regeneration research, 2018 - journals.lww.com
Alzheimer's disease (AD): AD, a neurodegenerative disorder and a significant cause of
dementia throughout the world mostly affects the older adults but sometimes also seen in …

Intranasal drug delivery for treatment of Alzheimer's disease

LC Fonseca, JA Lopes, J Vieira, C Viegas… - Drug Delivery and …, 2021 - Springer
The Alzheimer's disease is a neurodegenerative condition with severe consequences
interfering with patient quality of life. It is characterized as a progressive and irreversible …

Intranasal delivery of nanoformulations: a potential way of treatment for neurological disorders

SU Islam, A Shehzad, MB Ahmed, YS Lee - Molecules, 2020 - mdpi.com
Although the global prevalence of neurological disorders such as Parkinson's disease,
Alzheimer's disease, glioblastoma, epilepsy, and multiple sclerosis is steadily increasing …

Intranasal therapeutic strategies for management of Alzheimer's disease

S Sood, K Jain, K Gowthamarajan - Journal of drug targeting, 2014 - Taylor & Francis
Alzheimer's disease (AD) is a chronic and progressive age-related irreversible
neurodegenerative disorder that represents 70% of all dementia with 35 million cases …

Nose-to-brain delivery

P Giunchedi, E Gavini, MC Bonferoni - Pharmaceutics, 2020 - mdpi.com
Nose-to-brain delivery represents a big challenge. In fact there is a large number of
neurological diseases that require therapies in which the drug must reach the brain …

Recent patents review on intranasal administration for CNS drug delivery

A Misra, V Jogani, K Jinturkar… - Recent patents on drug …, 2008 - ingentaconnect.com
The treatment of brain disorders is the greatest challenge because of a variety of formidable
obstacles in effective drug delivery and maintaining therapeutic concentrations in the brain …

Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases

Q Huang, Y Chen, W Zhang, X Xia, H Li, M Qin… - Journal of Controlled …, 2024 - Elsevier
Despite the increasing global incidence of brain disorders, achieving sufficient delivery
towards the central nervous system (CNS) remains a formidable challenge in terms of …

Intranasal nanotherapeutics for brain targeting and clinical studies in Parkinson's disease

P Saha, H Kathuria, MM Pandey - Journal of Controlled Release, 2023 - Elsevier
Parkinson's disease (PD) is the second leading neurodegenerative disease globally,
impacting the quality of life of millions of people. It is estimated that the treatment cost of PD …

Insights into direct nose to brain delivery: current status and future perspective

D Mittal, A Ali, S Md, S Baboota, JK Sahni, J Ali - Drug delivery, 2014 - Taylor & Francis
Now a day's intranasal (in) drug delivery is emerging as a reliable method to bypass the
blood–brain barrier (BBB) and deliver a wide range of therapeutic agents including both …