P2X receptors belong to a family of cation channel proteins, which respond to extracellular
adenosine 5′-triphosphate (ATP). These receptors have gained increasing attention in …

The adenosine 5′-triphosphate-gated P2X4 receptor channel is a promising target in
neuroinflammatory disorders, but the ability to effectively target these receptors in models of …

Under various pathological conditions, including thrombosis and inflammation, extracellular
nucleotide levels may increase because of both active release and passive leakage from …

Thromboinflammation involves complex interactions between actors of inflammation and
immunity and components of the hemostatic system, which are elicited upon infection or …

Activation of P2Y1 and P2Y12 receptors, through secreted ADP that is stimulated by
agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet …

Extracellular nucleotides have been recognized as important mediators of activation,
triggering multiple responses via plasma membrane receptors known as P2 receptors. P2 …

P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the
extensive release of ATP induces sustained P2X7 receptor activation, culminating in …

Following vascular injury, the adenosine nucleotide ATP is released from the dense
granules of adhering and activated platelets, as well as from injured endothelial cells and …

P2X7 receptors are members of the ATP-gated cationic channel family with a preferential
localization at the microglial cells, the resident macrophages of the brain. However, these …

Extracellular nucleotides induce cellular responses in the central nervous system (CNS)
through the activation of ionotropic P2X and metabotropic P2Y nucleotide receptors …