Acute kidney injury (AKI) has been widely recognized as an important risk factor for the
occurrence and development of chronic kidney disease (CKD). Even milder AKI has adverse …

Abstract The kidneys compose approximately 0.5% of the body mass but consume about
10% of the oxygen in cellular respiration. This discordance is due to the high energy …

Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions,
and CKD is projected to become the fifth leading global cause of death by 2040. New …

While mitochondrial dysfunction is a pathological process that occurs after acute kidney
injury (AKI), the state of mitochondrial homeostasis during the injury and recovery phases of …

Acute kidney injury (AKI) is a common clinical entity that is associated with high mortality and
morbidity. It is a risk factor for the development and progression of chronic kidney disease …

AKI is associated with high morbidity and mortality, and it predisposes to the development
and progression of CKD. Novel strategies that minimize AKI and halt the progression of CKD …

Acute kidney injury (AKI) continues to be a significant contributor to morbidity, mortality, and
health care expenditure. In the United States alone, it is estimated that more than $10 billion …

Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI). The kidney
is susceptible to IRI under several clinical conditions, including hypotension, sepsis, and …

The kidney is a highly metabolic organ that requires substantial adenosine triphosphate for
the active transport required to maintain water and solute reabsorption. Aberrations in …