Converting human fibroblasts into personalized induced neural stem cells (hiNSC) that
actively seek out tumors and deliver cytotoxic agents is a promising approach for treating …

Engineered tumor-homing neural stem cells (NSCs) have shown promise in treating cancer.
Recently, we transdifferentiated skin fibroblasts into human-induced NSCs (hiNSC) as …

The spread of non-small cell lung cancer (NSCLC) to the leptomeninges is devastating with
a median survival of only a few months. Radiation offers symptomatic relief, but new …

Engineered neural stem cells (NSCs) are a promising approach to treating glioblastoma
(GBM). The ideal NSC drug carrier for clinical use should be easily isolated and autologous …

Triple-negative breast cancer (TNBC) is the most deadly subtype of breast cancer, with a
high incidence of brain metastasis. With the absence of targetable molecules on the cell …

Tumor-homing neural stem cell therapy (tNSC) is emerging as a promising treatment for
aggressive cancers of the brain. Despite their success, developing tNSC therapies that …

The conversion of human fibroblasts into personalized induced neural stem cells (iNSCs)
that actively seek out tumors and deliver cytotoxic agents is a highly promising approach for …

Cancer is one of the leading causes of morbidity and mortality worldwide, with 1,688,780
new cancer cases and 600,920 cancer deaths projected to occur in 2017 in the US alone …

Cancers of the brain remain one of the greatest medical challenges. Traditional surgery and
chemo-radiation therapy are unable to eradicate diffuse cancer cells and tumor recurrence …

Transdifferentiation (TD) is a recent advancement in somatic cell reprogramming. The direct
conversion of TD eliminates the pluripotent intermediate state to create cells that are ideal …