ABL-family proteins comprise one of the best conserved branches of the tyrosine kinases.
Each ABL protein contains an SH3-SH2-TK (Src homology 3–Src homology 2–tyrosine …

The mammalian ABL1 gene encodes the ubiquitously expressed nonreceptor tyrosine
kinase ABL. In response to growth factors, cytokines, cell adhesion, DNA damage, oxidative …

Simple Summary Protein phosphorylation is a key regulatory mechanism that controls a
wide variety of cellular responses. This process is catalysed by the members of the protein …

The Abelson tyrosine kinases were initially identified as drivers of leukemia in mice and
humans. The Abl family kinases Abl1 and Abl2 regulate diverse cellular processes during …

The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces
diverse extracellular signals to protein networks that control proliferation, survival, migration …

Abl kinases are prototypic cytoplasmic tyrosine kinases and are involved in a variety of
chromosomal aberrations in different cancers. This causes the expression of Abl fusion …

Mammalian c-Ablbelongs to an evolutionary conserved family of non-receptor tyrosine
kinases. It is distributed both in the cytoplasm in association with F-actin, and in the nucleus …

The Abelson (ABL) tyrosine kinases have been identified as drivers of leukemia in mice and
humans. Emerging data demonstrate a role for the ABL family kinases, ABL1 and ABL2, in …

From the Department of Biochemistry and Molecular Biophysics and Microbiology, Columbia
University College of Physicians and Surgeons, New York, New York 10032 v-Abl, encoded …

Aberrant tyrosine kinase activity plays a critical role in many hematologic disorders,
including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL …