Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18

LL Villa, KA Ault, AR Giuliano, RLR Costa, CA Petta… - Vaccine, 2006 - Elsevier
Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young
women (1106) were randomized to receive one of three formulations of a quadrivalent HPV …

Impact of baseline covariates on the immunogenicity of a quadrivalent (types 6, 11, 16, and 18) human papillomavirus virus-like-particle vaccine

AR Giuliano, E Lazcano-Ponce, L Villa… - The Journal of …, 2007 - academic.oup.com
Abstract Background. The quadrivalent (types 6, 11, 16, and 18) human papillomavirus
(HPV) L1 virus-like-particle vaccine was 95%–100% effective in preventing cervical and …

A phase I study to evaluate a human papillomavirus (HPV) type 18 L1 VLP vaccine

KA Ault, AR Giuliano, RP Edwards, G Tamms, LL Kim… - Vaccine, 2004 - Elsevier
Human papillomavirus (HPV) infection can cause genital warts and cervical cancer. HPV
types 6 and 11 cause> 90% of genital wart cases; HPV16 and 18 cause 70% of cervical …

Priming of human papillomavirus type 11-specific humoral and cellular immune responses in college-aged women with a virus-like particle vaccine

RT Emeny, CM Wheeler, KU Jansen, WC Hunt… - Journal of …, 2002 - Am Soc Microbiol
In this study, we evaluated the potency of a human papillomavirus (HPV) virus-like particle
(VLP)-based vaccine at generating HPV type 11 (HPV-11)-specific cellular and humoral …

Dose-ranging studies of the safety and immunogenicity of human papillomavirus Type 11 and Type 16 virus-like particle candidate vaccines in young healthy women

KH Fife, CM Wheeler, LA Koutsky, E Barr, DR Brown… - Vaccine, 2004 - Elsevier
Two candidate vaccines to prevent infection with human papillomavirus (HPV) Types 11 and
16 were studied in similar double-blind, placebo-controlled, dose-escalation trials. L1 virus …

Comparison of adaptive and innate immune responses induced by licensed vaccines for human papillomavirus

DM Herrin, EE Coates, PJ Costner… - Human vaccines & …, 2014 - Taylor & Francis
Two HPV virus-like particle (VLP) vaccines, HPV-16/18 (GlaxoSmithKline, Cervarix®) and
HPV-6/11/16/18 (Merck, Gardasil®), are currently licensed in the United States. Given the …

Early assessment of the efficacy of a human papillomavirus type 16 L1 virus-like particle vaccine

DR Brown, KH Fife, CM Wheeler, LA Koutsky… - Vaccine, 2004 - Elsevier
A post hoc analysis was performed using combined data from two Phase I tolerability/
immunogenicity studies of monovalent human papillomavirus type 11 (HPV11) or HPV16 L1 …

Prophylactic efficacy of a quadrivalent human papillomavirus (HPV) vaccine in women with virological evidence of HPV infection

Future II Study Group - The Journal of infectious diseases, 2007 - academic.oup.com
Abstract Background. A quadrivalent (types 6, 11, 16, and 18) human papillomavirus (HPV)
L1 virus-like-particle (VLP) vaccine has been shown to be 95%–100% effective in …

The impact of quadrivalent human papillomavirus (HPV; types 6, 11, 16, and 18) L1 virus-like particle vaccine on infection and disease due to oncogenic nonvaccine …

CM Wheeler, SK Kjaer, K Sigurdsson… - The Journal of …, 2009 - academic.oup.com
Background We evaluated the impact of a quadrivalent human papillomavirus (HPV)
vaccine on infection and cervical disease related to 10 nonvaccine HPV types (31, 33, 35 …

Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 vaccine and HPV-6/11/16/18 vaccine: follow-up from months 12–24 in a Phase III …

MH Einstein, M Baron, MJ Levin, A Chatterjee… - Human …, 2011 - Taylor & Francis
In this observer-blind study (NCT00423046), women (N= 1,106), stratified by age (18–26, 27–
35, 36–45 years), were randomized (1: 1) to receive the HPV-16/18 vaccine (Cervarix® …