The Complex Connection between Obesity and Cancer: Signaling Pathways and Therapeutic Implications

M El-Tanani, SA Rabbani, AA Aljabali… - Nutrition and …, 2024 - Taylor & Francis
Obesity has emerged as an important global health challenge, significantly influencing the
incidence and progression of various cancers. This comprehensive review elucidates the …

Translating mechanism-based strategies to break the obesity− cancer link: a narrative review

LA Smith, CH O'Flanagan, LW Bowers, EH Allott… - Journal of the Academy …, 2018 - Elsevier
Prevalence of obesity, an established risk factor for many cancers, has increased
dramatically over the past 50 years in the United States and across the globe. Relative to …

[HTML][HTML] Nutrition and physical activity in aging, obesity, and cancer

SD Hursting, SM Dunlap - Annals of the New York Academy of …, 2012 - ncbi.nlm.nih.gov
Obesity is an established risk and progression factor for many cancers. In the United States
more than one-third of adults, and nearly one in five children, are currently obese. Thus, a …

Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue

SD Hursting, SM Dunlap - Annals of the New York Academy of …, 2012 - Wiley Online Library
Obesity is an established risk and progression factor for many cancers. In the United States
more than one‐third of adults, and nearly one in five children, are currently obese. Thus, a …

Obesity and cancer risk: evidence, mechanisms, and recommendations

I Vucenik, JP Stains - Annals of the New York Academy of …, 2012 - Wiley Online Library
Obesity, a growing health problem worldwide, has been associated with the metabolic
syndrome, diabetes, cardiovascular disease, hypertension, and other chronic diseases …

A weighty problem: metabolic perturbations and the obesity-cancer link

CH O'Flanagan, LW Bowers… - … molecular biology and …, 2015 - degruyter.com
Obesity is an established risk factor for several cancers, including breast, colon, endometrial,
ovarian, gastric, pancreatic and liver, and is increasingly a public health concern. Obese …

Linking obesity, metabolism, and cancer

I Vucenik, LP Jones, JC McLenithan - Metabolic Syndrome: A …, 2024 - Springer
The pandemics of obesity and cancer are major health challenges worldwide. In addition to
diabetes and cardiovascular disease, epidemiological evidence shows that people who are …

Current mechanisms in obesity and tumor progression

A Fosam, RJ Perry - Current Opinion in Clinical Nutrition & …, 2020 - journals.lww.com
This review will highlight the present understanding of obesity, as it relates to tumor
development and progression. First, we will introduce the impact of obesity in cancer within …

Biological mechanisms for the effect of obesity on cancer risk: experimental evidence

M Berriel Diaz, S Herzig, T Schafmeier - Obesity and Cancer, 2016 - Springer
Multiple epidemiological studies demonstrated that overweight and obesity significantly
increase the risk of several types of cancer. As the prevalence of obesity is dramatically …

[HTML][HTML] Obesity and cancer metabolism: a perspective on interacting tumor–intrinsic and extrinsic factors

SS Doerstling, CH O'Flanagan, SD Hursting - Frontiers in oncology, 2017 - frontiersin.org
Obesity is associated with increased risk and poor prognosis of many types of cancers.
Several obesity-related host factors involved in systemic metabolism can influence tumor …