Patients with chronic pain often report being sensitive to pain at night before falling asleep, a
time when the synchronization of cortical activity is initiated. However, how cortical activity …

Chronic pain often leads to the development of sleep disturbances. However, the precise
neural circuit mechanisms responsible for sleep disorders in chronic pain have remained …

Differentiating between circadian rhythm and sleep's effect on pain is challenging, as these
two systems can be tightly coupled. A recent study by Daguet et al. found that circadian …

Spontaneous pain, a major complaint of patients with neuropathic pain, has eluded study
because there is no reliable marker in either preclinical models or clinical studies. Here, we …

Background Offset analgesia is a disproportionate decrease of pain perception following a
slight decrease of noxious thermal stimulus and attenuated in patients with neuropathic …

Insomnia is a common problem for people with chronic pain. Cortical GABAergic neurons
are part of the neurobiological substrate that underlies homeostatic sleep regulation. In the …

Background The increased pain sensitivity following reduced sleep may be related to
changes in cortical processing of nociceptive stimuli. Expectations shape pain perception …

Sex matters both in the clinical field of pain and sleep medicine. Sleep disturbances are
highly prevalent in chronic pain patients and have been shown to deteriorate the pain …

The nucleus accumbens (NAc) has been implicated in sleep, reward, and pain modulation,
but the relationship between these functional roles is unclear. This study aimed to determine …

Poor sleep is associated with the risk of developing chronic pain, but how sleep contributes
to pain chronicity remains unclear. Here we show that following peripheral nerve injury …