[HTML][HTML] Immune clearance of senescent cells to combat ageing and chronic diseases
Senescent cells are generally characterized by permanent cell cycle arrest, metabolic
alteration and activation, and apoptotic resistance in multiple organs due to various …
alteration and activation, and apoptotic resistance in multiple organs due to various …
Senescent cells: SASPected drivers of age-related pathologies
Y Ovadya, V Krizhanovsky - Biogerontology, 2014 - Springer
The progression of physiological ageing is driven by intracellular aberrations including
telomere attrition, genomic instability, epigenetic alterations and loss of proteostasis. These …
telomere attrition, genomic instability, epigenetic alterations and loss of proteostasis. These …
[HTML][HTML] Strategies targeting cellular senescence
Y Ovadya, V Krizhanovsky - The Journal of clinical …, 2018 - Am Soc Clin Investig
Cellular senescence is a physiological phenomenon that has both beneficial and
detrimental consequences. Senescence limits tumorigenesis and tissue damage throughout …
detrimental consequences. Senescence limits tumorigenesis and tissue damage throughout …
[HTML][HTML] Role of immune cells in the removal of deleterious senescent cells
Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a
complex senescence-associated secretory phenotype (SASP). The senescence arrest …
complex senescence-associated secretory phenotype (SASP). The senescence arrest …
Cellular senescence: immunosurveillance and future immunotherapy
DGA Burton, A Stolzing - Ageing research reviews, 2018 - Elsevier
In response to persistent DNA damage, induction into cell senescence promotes an
immunogenic program which facilitates immune clearance of these damaged cells. Under …
immunogenic program which facilitates immune clearance of these damaged cells. Under …
Senescent cell clearance by the immune system: Emerging therapeutic opportunities
LGPL Prata, IG Ovsyannikova, T Tchkonia… - Seminars in …, 2018 - Elsevier
Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory,
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …
[HTML][HTML] Targeting senescent cells: approaches, opportunities, challenges
C Von Kobbe - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
Cellular senescence is a hallmark of aging, whose onset is linked to a series of both cell and
non-cell autonomous processes, leading to several consequences for the organism. To …
non-cell autonomous processes, leading to several consequences for the organism. To …
[HTML][HTML] Targeting cellular senescence in metabolic disease
AK Palmer, T Tchkonia, JL Kirkland - Molecular Metabolism, 2022 - Elsevier
Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis,
and the development of a secretome that can be pro-inflammatory. In aging and obesity …
and the development of a secretome that can be pro-inflammatory. In aging and obesity …
Immunosurveillance of senescent cells: the bright side of the senescence program
A Sagiv, V Krizhanovsky - Biogerontology, 2013 - Springer
Cellular senescence, a state of irreversible cell cycle arrest, is a robust mechanism used to
mediate tumor suppression and control the tissue damage response following short-term …
mediate tumor suppression and control the tissue damage response following short-term …
[HTML][HTML] Strategies for targeting senescent cells in human disease
Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …