Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
Heritability of regional brain volumes in large-scale neuroimaging and genetic studies
Brain genetics is an active research area. The degree to which genetic variants impact
variations in brain structure and function remains largely unknown. We examined the …
variations in brain structure and function remains largely unknown. We examined the …
The genetic architecture of the human cerebral cortex
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …
Variations in human cortical surface area and thickness are associated with neurological …
[HTML][HTML] Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence
The phenotypic correlation between human intelligence and brain volume (BV) is
considerable (r≈ 0.40), and has been shown to be due to shared genetic factors. To further …
considerable (r≈ 0.40), and has been shown to be due to shared genetic factors. To further …
[HTML][HTML] Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Cortical thickness, surface area and volumes vary with age and cognitive function, and in
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …
[HTML][HTML] Understanding the genetic determinants of the brain with MOSTest
Regional brain morphology has a complex genetic architecture, consisting of many common
polymorphisms with small individual effects. This has proven challenging for genome-wide …
polymorphisms with small individual effects. This has proven challenging for genome-wide …
Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
Novel genetic loci underlying human intracranial volume identified through genome-wide association
Intracranial volume reflects the maximally attained brain size during development, and
remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes …
remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes …
[HTML][HTML] Mapping the genetic architecture of cortical morphology through neuroimaging: progress and perspectives
D van der Meer, T Kaufmann - Translational Psychiatry, 2022 - nature.com
Cortical morphology is a key determinant of cognitive ability and mental health. Its
development is a highly intricate process spanning decades, involving the coordinated …
development is a highly intricate process spanning decades, involving the coordinated …
Common variants at 6q22 and 17q21 are associated with intracranial volume
Nature genetics, 2012 - nature.com
During aging, intracranial volume remains unchanged and represents maximally attained
brain size, while various interacting biological phenomena lead to brain volume loss …
brain size, while various interacting biological phenomena lead to brain volume loss …