Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Acetaminophen (APAP)-induced liver injury is an important clinical and toxicological
problem. Understanding the mechanisms and modes of cell death are vital for the …

There is a significant need to evaluate the therapeutic potential of natural products and other
compounds purported to be hepatoprotective. Acetaminophen-induced liver injury …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …

Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the
United States and mechanisms of liver injury induced by APAP overdose have been the …

Over the past five or more years, laboratory and clinical investigations aimed at elucidating
the pathogenesis of acetaminophen-induced liver-cell necrosis have achieved a striking …

Acetaminophen (APAP) is a highly effective analgesic, which is safe at therapeutic doses.
However, an overdose can cause hepatotoxicity and even liver failure. APAP toxicity is …

Background: Drug-induced liver injury is a rare but serious clinical problem. A number of
drugs can cause severe liver injury and acute liver failure at therapeutic doses in a very …