[HTML][HTML] Safranal Inhibits Angiogenesis via Targeting HIF-1α/VEGF Machinery: In Vitro and Ex Vivo Insights

A Abdalla, C Murali, A Amin - Frontiers in Oncology, 2022 - frontiersin.org
Nature has a nearly infinite inventory of unexplored phytochemicals and biomolecules that
have the potential to treat a variety of diseases. Safranal exhibits anti-cancer property and …

[HTML][HTML] Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling

P Liu, SJ Atkinson, SE Akbareian, Z Zhou… - Scientific reports, 2017 - nature.com
Angiogenesis plays an important role in hepatocellular carcinoma (HCC), the inhibition of
which is explored for cancer prevention and treatment. The dietary phytochemical …

[HTML][HTML] Safranal prevents liver cancer through inhibiting oxidative stress and alleviating inflammation

Y Abdalla, A Abdalla, AA Hamza, A Amin - Frontiers in Pharmacology, 2022 - frontiersin.org
Despite all efforts, an effective and safe treatment for liver cancer remains elusive. Natural
products and their derived biomolecules are potential resources to mine for novel anti …

Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades

JH Lee, S Choi, Y Lee, HJ Lee, KH Kim, KS Ahn… - Molecular cancer …, 2010 - AACR
Farnesiferol C (FC) is one of the major compounds isolated from Ferula assafoetida, an
Asian herbal spice used for cancer treatment as a folk remedy. Here, we examined the …

Cryptotanshinone inhibits VEGF-induced angiogenesis by targeting the VEGFR2 signaling pathway

X Xu, L Wu, X Zhou, N Zhou, Q Zhuang, J Yang… - Microvascular …, 2017 - Elsevier
Objective Anti-angiogenesis has been proposed as an important strategy for angiogenesis-
related diseases. Cryptotanshinone (CPT), an active component of Salvia miltiorrhiza, may …

Cinnamon extract reduces VEGF expression via suppressing HIF‐1α gene expression and inhibits tumor growth in mice

K Zhang, ES Han, TH Dellinger, J Lu… - Molecular …, 2017 - Wiley Online Library
Although many anti‐VEGF agents are available for cancer treatment, side effects of these
agents limit their application for cancer treatment and prevention. Here we studied the …

Antiangiogenic effects of flavonoids and chalcones

J Mojzis, L Varinska, G Mojzisova, I Kostova… - Pharmacological …, 2008 - Elsevier
Angiogenesis, the development of new blood vessels from the existing vasculature, is
essential in normal developmental processes. Uncontrolled angiogenesis is a major …

Physalin B inhibits PDGF-BB-induced VSMC proliferation, migration and phenotypic transformation by activating the Nrf2 pathway

L Qiu, L Hu, X Liu, W Li, X Zhang, H Xia, C Zhang - Food & Function, 2021 - pubs.rsc.org
Vascular intimal hyperplasia is a hallmark event in vascular restenosis. The excessive
proliferation, migration and phenotypic transformation of vascular smooth muscle cells …

Crocetin suppresses angiogenesis and metastasis through inhibiting sonic hedgehog signaling pathway in gastric cancer

M Zang, J Hou, Y Huang, J Wang, X Ding… - Biochemical and …, 2021 - Elsevier
Gastric cancer (GC) is one of the major causes of cancer-related deaths and
chemoresistance is a key obstacle to the treatment of GC, particularly in advanced GC. As …

[PDF][PDF] Webba Da Silva, M.; McCarron, PA; Tambuwala, MM Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways. Cells …

HA Bakshi, GA Quinn, MM Nasef, V Mishra… - 2022 - academia.edu
Angiogenesis and metastasis play pivotal roles in the progression of cancer. We recently
discovered that crocin, a dietary carotenoid derived from the Himalayan crocus, inhibited the …