Wnts are conserved, secreted signaling proteins that can influence cell behavior by
stabilizing β-catenin. Accumulated β-catenin enters the nucleus, where it physically …

Embryonic signaling pathways often lead to a switch from default repression to
transcriptional activation of target genes. A major consequence of Wnt signaling is …

The Wnt-signaling cascade plays critical roles in embryonic patterning, cell fate
determination, and tissue homeostasis. When secreted Wnt factors bind to their receptors, a …

T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end
point mediators of Wnt/Wingless signaling throughout metazoans. TCF/LEFs are …

The regulation of many targets of the Wnt/β-catenin signaling pathway is thought to occur
through a transcriptional switch that is achieved by β-catenin binding to TCF transcription …

Wnt/β-catenin signaling is highly conserved throughout metazoans, is required for numerous
essential events in development, and serves as a stem cell niche signal in many contexts …

Wnt molecules control numerous developmental processes by altering specific gene
expression patterns, and deregulation of Wnt signaling can lead to cancer. Many Wnt factors …

The Wnt/β-catenin pathway is a conserved cell-cell signalling mechanism in animals that
regulates gene expression via TCF/LEF DNA-binding factors to coordinate many cellular …

Abstract T-cell factor (Tcf)/lymphoid-enhancer factor (Lef) proteins are a structurally diverse
family of deoxyribonucleic acid-binding proteins that have essential nuclear functions in …

The canonical Wnt/β-catenin signaling pathway classically functions through the activation
of target genes by Tcf/Lef–β-catenin complexes. In contrast to β-catenin-dependent functions …