Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors
are strongly associated with its development; however, recently it has been observed that …

OBJECTIVE: To review the current knowledge of the mechanism of DNA methylation, its
association with transcriptional silencing, possible mechanisms of hyper-and …

Osteoarthritis (OA) is a prevalent disease of articular joints and primarily characterized by
degradation and calcification of articular cartilage. Presently, no effective treatment other …

Abstract Purpose of Review Epigenomics has emerged as a key player in our rapidly
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …

Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints
resulting from the age-associated loss of cartilage. Well-powered genetic studies have …

A variety of osteoarticular conditions possess an underlying genetic aetiology. Large-scale
genome-wide association studies have identified several genetic loci associated with …

Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …

Osteoarthritis (OA) is a complicated disease with both hereditary and environmental causes.
Despite an increase in reports of possible OA risk loci, it has become clear that genetics is …

Objective To identify osteoarthritis (OA) progression–modulating pathways in articular
cartilage and their respective regulatory epigenetic and genetic determinants in end‐stage …