Objective Tissue injury and inflammation are two potential outcomes of cerebral ischemia–
reperfusion (I/R) injury. Salvianolic acid B (Sal B), isolated from the roots of Salvia …

Neuroinflammation plays a critical role in the pathogenesis of ischemia/reperfusion (I/R)
injury. Activated platelets are increasingly regarded as initiators and/or amplifiers of …

Background Cerebral ischemia-reperfusion injury (CIRI) is a phenomenon that pathological
injury of ischemic brain tissue is further aggravated after the restoration of blood supply. The …

Background Stroke is a leading cause of mortality and disability with ischemic stroke being
the most common type of stroke. Salvianolic acid C (SalC), a polyphenolic compound found …

Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza
Bge, a traditional Chinese medicine, which has been used for the treatment of …

Background and objectives: Salvianolic acid A (SAA) is a main component derived from
Salvia miltiorrhiza and has been revealed to protect against cerebral ischemia/reperfusion …

Ischemic stroke can activate multiple transcription factors and cause inflammatory reactions,
which involve pattern recognition receptors with immunostimulatory effects. Toll-like receptor …

Background Toll-like receptor 2 and Toll-like receptor 4 (TLR2/4) on microglia have been
found as important regulators in the inflammatory response during cerebral …

The purpose of this study was to evaluate the cerebral protection of salvianolic acid B (Sal B)
against cerebral I/R injury and investigate the underlying mechanism. As shown by 2, 3, 5 …

This study aimed to investigate the mechanism of salvianolic acid C (SAC), the active
ingredient in Salvia miltiorrhiza, in improving cerebral ischemia injury. The mouse microglial …