Abstract Liver receptor homolog-1 (LRH1) has been shown to promote tumor proliferation
and development. However, the functions of LRH1 in mediating cancer cells …

Abstract Liver receptor homologue 1 (LRH-1) is an orphan nuclear receptor that has been
implicated in the progression of breast, pancreatic and colorectal cancer (CRC). To …

Background To explore potential therapeutic target is one of the areas of great interest in
both clinical and basic hepatocellular carcinoma (HCC) studies. Nuclear receptor liver …

The orphan nuclear receptor liver receptor homologue-1 (LRH-1) has roles in the
development, cholesterol and bile acid homeostasis, and steroidogenesis. It also enhances …

Loss of apico-basal polarity often results in a malignant phenotype in epithelial tissues.
Aberrant expression of polarity mediator proteins is closely associated with this process …

Hepatoblastoma is the most common malignant liver tumor in children. Since it is often
unresectable and exhibits drug resistance, the treatment of advanced hepatoblastoma is …

Abstract Liver receptor homolog-1 (LRH-1) is a nuclear receptor previously known to have
distinct functions during mouse development and essential roles in cholesterol homeostasis …

Tumor characteristics are decisive in the determination of treatment strategy for patients with
breast cancer. Patients with estrogen receptor α (ERα)–positive breast cancer can benefit …

Estrogen receptor-α (ER) is expressed in the great majority of breast cancers, and the
inhibition of ER action is a key part of breast cancer treatment. The inhibition of ER action is …

The transcriptional factor liver receptor homolog 1 (LRH1) regulates pancreatic
development, and may participate in pancreatic oncogenesis through activation of growth …