The emergence of bioorthogonal reactions has provided numerous opportunities for the
design and fabrication of innovative fluorescence systems, particularly in the analytical field …

The use of covalent chemistry to track biomolecules in their native environment—a focus of
bioorthogonal chemistry—has received considerable interest recently among chemical …

Copper-catalyzed and copper-free sydnone–alkyne cycloaddition reactions have emerged
as complementary click tools for chemical biology but their use in bioorthogonal labeling is …

Bioorthogonal chemistry has enabled the selective labeling and detection of biomolecules in
living systems. Bioorthogonal smart probes, which become fluorescent or deliver imaging or …

Conspectus For more than 15 years, bioorthogonal chemistry has received increasing
attention due to its successful applications in the detection and imaging of biomolecules in …

Bioorthogonal chemistry has offered an invaluable reactivity-based tool to chemical biology
owing to its exquisite specificity in tagging a diverse set of biomolecules in their native …

Since the term “bioorthogonal” was first demonstrated in 2003, new tools for bioorthogonal
chemistry have been rapidly developed. Bioorthogonal chemistry has now been widely …

Fluorescence imaging is an important method in the field of biomedicine. Fluorescence
imaging is nondestructive, has high efficiency and sensitivity, high resolution and allows real …

Bioorthogonal reactions are of high interest in biosciences as they allow the introduction of
fluorescent dyes, affinity tags, or other unnatural moieties into biomolecules. The site …

Conspectus Chemical tools are transforming our understanding of biomolecules and living
systems. Included in this group are bioorthogonal reagents–functional groups that are inert …