Targeting renal proximal tubule cells in obesity-related glomerulopathy

M Ye, M Yang, W Dai, H Li, X Zhou, Y Chen, L He - Pharmaceuticals, 2023 - mdpi.com
As a metabolic disorder, obesity can cause secondary kidney damage, which is called
obesity-related glomerulopathy (ORG). As the incidence of obesity increases worldwide, so …

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

T Xu, Z Sheng, L Yao - Frontiers of medicine, 2017 - Springer
In light of the rapid increase in the number of obesity incidences worldwide, obesity has
become an independent risk factor for chronic kidney disease. Obesity-related …

Obesity-related glomerulopathy: from mechanism to therapeutic target

L Wei, Y Li, Y Yu, M Xu, H Chen, L Li… - Diabetes, Metabolic …, 2021 - Taylor & Francis
Obesity-related glomerulopathy (ORG) is a secondary glomerular disease caused by
obesity, with clinical manifestations such as proteinuria and glomerulomegaly. Currently, the …

Novel insights in the physiopathology and management of obesity-related kidney disease

J Sandino, M Martín-Taboada, G Medina-Gómez… - Nutrients, 2022 - mdpi.com
Obesity is recognized as an independent risk factor for the development of kidney disease,
which has led to the designation of obesity-related glomerulopathy (ORG). Common renal …

Obesity-related glomerulopathy: recent advances in inflammatory mechanisms and related treatments

Y Guan, X Wei, J Li, Y Zhu, P Luo… - Journal of Leukocyte …, 2024 - academic.oup.com
Obesity-related glomerulopathy, which is an obesity-triggered kidney damage, has become
a significant threat to human health. Several studies have recently highlighted the critical …

[HTML][HTML] Mitochondrial dysfunction in obesity-related kidney disease: a novel therapeutic target

C Tang, J Cai, Z Dong - Kidney international, 2016 - Elsevier
Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related
kidney disease, but the underlying mechanism is poorly understood. Szeto et al. now …

Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples

Y Wu, Z Liu, Z Xiang, C Zeng, Z Chen, X Ma… - Endocrinology, 2006 - academic.oup.com
Obesity-related glomerulopathy (ORG) is an important complication of obesity. The
pathophysiological mechanism of glomerular injury in ORG is incompletely understood …

The New Challenge of Obesity-Obesity-Associated Nephropathy

M Hao, Y Lv, S Liu, W Guo - Diabetes, Metabolic Syndrome and …, 2024 - Taylor & Francis
In recent years, obesity has become one of the major diseases that affect human health and
consume human health resources, especially when it causes comorbidities such as …

Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis

VD D'Agati, A Chagnac, AP De Vries, M Levi… - Nature Reviews …, 2016 - nature.com
The prevalence of obesity-related glomerulopathy is increasing in parallel with the
worldwide obesity epidemic. Glomerular hypertrophy and adaptive focal segmental …

New pandemic: obesity and associated nephropathy

I Sharma, Y Liao, X Zheng, YS Kanwar - Frontiers in medicine, 2021 - frontiersin.org
Incidence of obesity related renal disorders have increased 10-folds in recent years. One of
the consequences of obesity is an increased glomerular filtration rate (GFR) that leads to the …