Extracellular matrix (ECM) remodeling has emerged as a key feature of inflammatory bowel
disease (IBD), and ECM fragments have been proposed as markers of clinical disease …

Background Proteolytic degradation of the extracellular matrix, a feature of mucosal
homeostasis and tissue renewal, also contributes to the complications of intestinal …

Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix
remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic …

Alterations in gut microbiota have been implicated in the pathogenesis of inflammatory
bowel disease (IBD), however factors that mediate the host–microbiota interactions remain …

Background Increased protease activity is a key pathological feature of inflammatory bowel
disease (IBD). However, the differences in extracellular matrix remodelling (ECM) in Crohn's …

Simple Summary For decades, the extracellular matrix (ECM) has been defined as a
structure component playing a rather neglected role in the human body. In recent years …

Microbial dysbiosis characterized by alterations in the structure and function of the gut
microbiome has long been implicated in the pathogenesis of inflammatory bowel disease …

The intestinal epithelium is constantly regenerating due to its continuous exposure to the
mechanical and microbial damage from the external environment. Intestinal homeostasis is …

IBD, which primarily includes UC and Crohn's disease (CD), is a progressive, chronic and
relapsing condition. This debilitating disease is steadily becoming a worldwide medical …

Introduction: Extracellular matrix (ECM) remodeling of the intestinal tissue is important in
inflammatory bowel disease (IBD) due to the extensive mucosal remodeling. There are still …