The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …

During innate immune responses, proteostasis is greatly impacted by synthesis of pathogen
proteins as well as by inflammatory tissue damage through radicals or other damaging …

Protein degradation through the ubiquitin-proteasome system is the major pathway of non-
lysosomal proteolysis of intracellular proteins. It plays important roles in a variety of …

Ubiquitination is a post‐translational modification process that has been implicated in the
regulation of innate and adaptive immune responses. There is increasing evidence that both …

The ubiquitin system plays a pivotal role in the regulation of immune responses. This system
includes a large family of E3 ubiquitin ligases of over 700 proteins and about 100 …

The ubiquitin proteasomal system (UPS) represents a highly regulated protein degradation
pathway essential for maintaining cellular homeostasis. This system plays a critical role in …

Ubiquitination, the covalent attachment of ubiquitin molecules to proteins, is emerging as a
widely utilized mechanism for rapidly regulating cell signaling. Recent studies indicate that …

Ubiquitin is a post-translational protein modifier and plays essential roles in all aspects of
biology. Although the discovery of ubiquitin introduced this highly conserved protein as a …

The immunoproteasome is a specific proteasome isoform induced by interferons. Its
proteolytic function has been almost exclusively connected with the adaptive immune …

Regulatory functions of the ubiquitin-proteasome system (UPS) are exercised mainly by the
ubiquitin ligases and deubiquitinating enzymes. Degradation of apoptotic proteins by UPS is …