[HTML][HTML] Pre-fusion F is absent on the surface of formalin-inactivated respiratory syncytial virus

AM Killikelly, M Kanekiyo, BS Graham - Scientific reports, 2016 - nature.com
The lack of a licensed vaccine for respiratory syncytial virus (RSV) can be partly attributed to
regulatory hurdles resulting from vaccine enhanced respiratory disease (ERD) subsequent …

A monomeric uncleaved respiratory syncytial virus F antigen retains prefusion-specific neutralizing epitopes

KA Swanson, K Balabanis, Y Xie, Y Aggarwal… - Journal of …, 2014 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is the leading infectious cause of severe respiratory
disease in infants and a major cause of respiratory illness in the elderly. There remains an …

Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera

JO Ngwuta, M Chen, K Modjarrad, MG Joyce… - Science translational …, 2015 - science.org
Respiratory syncytial virus (RSV) is estimated to claim more lives among infants< 1 year old
than any other single pathogen, except malaria, and poses a substantial global health …

[HTML][HTML] Immunological lessons from respiratory syncytial virus vaccine development

TJ Ruckwardt, KM Morabito, BS Graham - Immunity, 2019 - cell.com
Respiratory syncytial virus (RSV) has eluded active vaccination efforts for more than five
decades and continues to cause substantial morbidity and mortality in infants, the …

Vaccines against respiratory syncytial virus: the time has finally come

BS Graham - Vaccine, 2016 - Elsevier
Respiratory syncytial virus causes a significant public health burden, particularly in very
young infants and the frail elderly. The legacy of enhanced RSV disease (ERD) from a …

Clinical potential of prefusion RSV F-specific antibodies

I Rossey, JS McLellan, X Saelens, B Schepens - Trends in microbiology, 2018 - cell.com
Human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract
infections in the very young. The RSV fusion protein (F) is essential for virus entry because it …

Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus

JS McLellan, M Chen, MG Joyce, M Sastry… - science, 2013 - science.org
Respiratory syncytial virus (RSV) is the leading cause of hospitalization for children under 5
years of age. We sought to engineer a viral antigen that provides greater protection than …

Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers

KA Swanson, EC Settembre… - Proceedings of the …, 2011 - National Acad Sciences
Respiratory syncytial virus (RSV), the main cause of infant bronchiolitis, remains a major
unmet vaccine need despite more than 40 years of vaccine research. Vaccine candidates …

Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein elicits antibodies targeting a membrane-proximal epitope

RS McCool, M Musayev, SM Bush… - Journal of …, 2023 - Am Soc Microbiol
Respiratory syncytial virus (RSV) causes tens of millions of acute lower respiratory tract
infections and millions of hospital admissions globally each year. An antibody repertoire …

A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein

JJ Mousa, N Kose, P Matta, P Gilchuk, JE Crowe - Nature microbiology, 2017 - nature.com
Respiratory syncytial virus (RSV) remains a major human pathogen, infecting the majority of
infants before age two and causing re-infection throughout life. Despite decades of RSV …