[HTML][HTML] Fos ensembles encode and shape stable spatial maps in the hippocampus

NL Pettit, EL Yap, ME Greenberg, CD Harvey - Nature, 2022 - nature.com
In the hippocampus, spatial maps are formed by place cells while contextual memories are
thought to be encoded as engrams,,,,–. Engrams are typically identified by expression of the …

Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network

EL Yap, NL Pettit, CP Davis, MA Nagy, DA Harmin… - Nature, 2021 - nature.com
Behavioural experiences activate the FOS transcription factor in sparse populations of
neurons that are critical for encoding and recalling specific events,–. However, there is …

Parallel emergence of stable and dynamic memory engrams in the hippocampus

T Hainmueller, M Bartos - Nature, 2018 - nature.com
During our daily life, we depend on memories of past experiences to plan future behaviour.
These memories are represented by the activity of specific neuronal groups or 'engrams' …

Calcium transient prevalence across the dendritic arbour predicts place field properties

MEJ Sheffield, DA Dombeck - Nature, 2015 - nature.com
Establishing the hippocampal cellular ensemble that represents an animal's environment
involves the emergence and disappearance of place fields in specific CA1 pyramidal …

A hippocampal network for spatial coding during immobility and sleep

K Kay, M Sosa, JE Chung, MP Karlsson, MC Larkin… - Nature, 2016 - nature.com
How does an animal know where it is when it stops moving? Hippocampal place cells fire at
discrete locations as subjects traverse space, thereby providing an explicit neural code for …

[HTML][HTML] ΔFosB accumulation in hippocampal granule cells drives cFos pattern separation during spatial learning

PJ Lamothe-Molina, A Franzelin, L Beck, D Li… - Nature …, 2022 - nature.com
Mice display signs of fear when neurons that express cFos during fear conditioning are
artificially reactivated. This finding gave rise to the notion that cFos marks neurons that …

Long-term dynamics of CA1 hippocampal place codes

Y Ziv, LD Burns, ED Cocker, EO Hamel, KK Ghosh… - Nature …, 2013 - nature.com
Using Ca2+ imaging in freely behaving mice that repeatedly explored a familiar
environment, we tracked thousands of CA1 pyramidal cells' place fields over weeks. Place …

Recalibration of path integration in hippocampal place cells

RP Jayakumar, MS Madhav, F Savelli, HT Blair… - Nature, 2019 - nature.com
Hippocampal place cells are spatially tuned neurons that serve as elements of a 'cognitive
map'in the mammalian brain. To detect the animal's location, place cells are thought to rely …

Local circuit amplification of spatial selectivity in the hippocampus

T Geiller, S Sadeh, SV Rolotti, H Blockus, B Vancura… - Nature, 2022 - nature.com
Local circuit architecture facilitates the emergence of feature selectivity in the cerebral
cortex. In the hippocampus, it remains unknown whether local computations supported by …

Intracellular dynamics of hippocampal place cells during virtual navigation

CD Harvey, F Collman, DA Dombeck, DW Tank - Nature, 2009 - nature.com
Hippocampal place cells encode spatial information in rate and temporal codes. To examine
the mechanisms underlying hippocampal coding, here we measured the intracellular …