AGE/RAGE signaling has been a well‐studied cascade in many different disease states,
particularly diabetes. Due to the complex nature of the receptor and multiple intersecting …

Advanced-glycation end products (AGEs) were recently implicated in vascular calcification,
through a process mediated by RAGE (receptor for AGEs). Although a correlation between …

Recent meta-analyses have revealed that the risk of bone fracture is increased in both type
1 and type 2 diabetic patients. Low bone mineral density (BMD) can not necessarily explain …

Advanced glycation end-products (AGEs), senescent macroprotein derivatives formed at an
accelerated rate in diabetes, are closely associated with vascular calcification in humans. In …

Background Arterial media calcification (AMC) is highly prevalent and is a major cause of
morbidity, mortality, stroke and amputation in patients with diabetes mellitus (DM). Previous …

Background: Mönckeberg's calcification in diabetes, known as medial artery calcification, is
an independent predictor of cardiovascular mortality. However, the mechanism underlying …

Diabetes mellitus is a multifactorial disease, classically influenced by genetic determinants
of individual susceptibility and by environmental accelerating factors, such as lifestyle. It is …

Diabetes compromises bone cell metabolism and function, resulting in increased risk of
fragility fracture. Advanced glycation end products (AGEs) interact with the receptor for AGEs …

Vascular calcification (VC) has been well-established as an independent and strong
predictor of cardiovascular diseases (CVD) as well as major cardiac adverse events …

The continuing increase in the prevalence of diabetes mellitus in the general population is
predicted to result in a higher incidence of cardiovascular disease. Although the …