The C3 enzymes from Clostridium (C.) botulinum (C3bot) and Clostridium limosum (C3lim)
are single chain protein toxins of about 25 kDa that mono-ADP-ribosylate Rho-A,-B, and-C …

C3 protein toxins produced by Clostridium (C.) botulinum and C. limosum are mono-ADP-
ribosyltransferases, which specifically modify the GTPases Rho A/B/C in the cytosol of …

The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the
enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects …

Bacterial protein toxins became valuable molecular tools for the targeted modulation of cell
functions in experimental pharmacology and attractive therapeutics because of their potent …

The C3 transferases from Clostridium botulinum (C3bot) and Clostridium limosum (C3lim)
mono‐ADP‐ribosylate and thereby inactivate RhoA,‐B and‐C of eukaryotic cells. Due to …

Clostridium botulinum produces a binary toxin, which is composed of two separate proteins.
The enzyme component, C2I, is an ADP-ribosyltransferase which modifies G-actin of …

The Clostridium botulinum C3 exoenzyme selectively ADP-ribosylates low molecular weight
GTP-binding proteins RhoA, B and C. This covalent modification inhibits Rho signaling …

The binary Clostridium botulinum C2 toxin consists of two separate proteins, the binding
component C2II (80.5 kDa) and the actin-ADP-ribosylating enzyme component C2I (49.4 …

Background The C3bot1 protein (∼ 23 kDa) from Clostridium botulinum ADP-ribosylates
and thereby inactivates Rho. C3bot1 is selectively taken up into the cytosol of monocytes …

Clostridium botulinum adenosine diphosphate (ADP)—ribosyltransferase C3 was the first
bacterial exoenzyme/toxin found to act on small guanosine triphosphate (GTP) ases of the …