mRNA vaccine era—mechanisms, drug platform and clinical prospection

S Xu, K Yang, R Li, L Zhang - International journal of molecular sciences, 2020 - mdpi.com
Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …

mRNA as a transformative technology for vaccine development to control infectious diseases

G Maruggi, C Zhang, J Li, JB Ulmer, D Yu - Molecular Therapy, 2019 - cell.com
In the last two decades, there has been growing interest in mRNA-based technology for the
development of prophylactic vaccines against infectious diseases. Technological …

mRNA vaccines in disease prevention and treatment

G Zhang, T Tang, Y Chen, X Huang… - Signal transduction and …, 2023 - nature.com
Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …

Advances in mRNA vaccines for infectious diseases

C Zhang, G Maruggi, H Shan, J Li - Frontiers in immunology, 2019 - frontiersin.org
During the last two decades, there has been broad interest in RNA-based technologies for
the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have …

[HTML][HTML] mRNA vaccines—a new era in vaccinology

N Pardi, MJ Hogan, FW Porter… - Nature reviews Drug …, 2018 - nature.com
Abstract mRNA vaccines represent a promising alternative to conventional vaccine
approaches because of their high potency, capacity for rapid development and potential for …

The promise of mRNA vaccines: a biotech and industrial perspective

NAC Jackson, KE Kester, D Casimiro, S Gurunathan… - npj Vaccines, 2020 - nature.com
Abstract mRNA technologies have the potential to transform areas of medicine, including the
prophylaxis of infectious diseases. The advantages for vaccines range from the acceleration …

Recent advances in mRNA vaccine technology

N Pardi, MJ Hogan, D Weissman - Current opinion in immunology, 2020 - Elsevier
Highlights•mRNA vaccines address many of the weaknesses of conventional vaccine
types.•Innovations in recent years revolutionized the applicability of mRNA vaccines.•mRNA …

[HTML][HTML] mRNA vaccines: Past, present, future

M Karam, G Daoud - Asian journal of pharmaceutical sciences, 2022 - Elsevier
Abstract mRNA vaccines have emerged as promising alternative platforms to conventional
vaccines. Their ease of production, low cost, safety profile and high potency render them …

Development of mRNA vaccines: scientific and regulatory issues

I Knezevic, MA Liu, K Peden, T Zhou, HN Kang - Vaccines, 2021 - mdpi.com
The global research and development of mRNA vaccines have been prodigious over the
past decade, and the work in this field has been stimulated by the urgent need for rapid …

Development and delivery systems of mRNA vaccines

Y Liang, L Huang, T Liu - Frontiers in Bioengineering and …, 2021 - frontiersin.org
Since the outbreak of SARS-CoV-2, mRNA vaccine development has undergone a
tremendous drive within the pharmaceutical field. In recent years, great progress has been …