Neutrophils, the largest innate immune cell population in humans, are the primary
proinflammatory sentinel in the ischemia-reperfusion injury (IRI) mechanism in orthotopic …

Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and
metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We …

Liver transplantation can be a life-saving treatment for end-stage hepatic disease.
Unfortunately, some recipients develop ischemia-reperfusion injury (IRI) that leads to poor …

Abstract Purpose of Review Hepatic ischemia-reperfusion injury (IRI), an inevitable event
during liver transplantation, represents a major risk factor for the primary graft dysfunction as …

Many end-stage liver disease etiologies are attributed to robust inflammatory cell
recruitment. Neutrophils play an important role in inflammatory infiltration and neutrophil …

Background Liver ischemia/reperfusion (I/R) injury is a type of uncontrolled inflammatory
cascade in which neutrophils, an early infiltrating immune cell population, elicit significant …

The innate immune system plays an essential role in the response to sterile inflammation
and its association with liver ischemia and reperfusion injury (IRI). Liver IRI often manifests …

Tribbles pseudokinase 1 (Trib1) is a negative regulator of CCAAT/enhancer binding protein
α (C/EBPα) and is known to induce granulopoiesis while suppressing monocyte …

Abstract Background Neutrophil extracellular traps (NETs) play a crucial role in host
defense, but excess and prolonged interaction of NETs with platelets can cause severe …

The damage-associated molecular pattern molecules (DAMPs) released by necrotic cells
can trigger inflammatory response, which will facilitate the clearance of these dead cells …