N-Glycosylases excise the damaged adducts from DNA. 7, 8-Dihydro-8-oxoguanine in
human cells is repaired by OGG1 and hNTH1. The activities of hOGG1 and hNTH1 were …

In humans, the oxidatively induced DNA lesion 8-hydroxyguanine (8-oxoG) is removed from
DNA by hOgg1, a DNA glycosylase/AP lyase that specifically incises 8-oxoG opposite …

The hOGG1 gene encodes a DNA glycosylase that excises 8-hydroxyguanine (oh 8 Gua)
from damaged DNA. Structural analyses of the hOGG1 gene and its transcripts were …

Hexavalent chromium is a genotoxic human pulmonary carcinogen that elevates DNA
oxidation, apparently through the generation of reactive DNA-damaging intermediates …

Objective The human 8-oxoguanine DNA N-glycosylase 1 gene encodes a DNA
glycosylase that is involved in the base excision repair of 8-hydroxy-2-deoxyguanine from …

Background: Although smoking is a major cause of lung cancer, only a proportion of
smokers develop lung cancer, suggesting a genetic predisposition in some individuals …

Reactive oxygen species produced by aerobic cellular metabolism or through exposure to
environmental carcinogens can cause oxidative DNA damage by generating DNA base …

Abstract Human 8‐oxoguanine DNA glycosylase 1 (hOGG1) plays a major role in the repair
of 8‐hydroxyguanine, one of the major forms of DNA damage generated by reactive oxygen …

DNA glycosylase, encoded by the hOGG1 gene, repairs 8‐hydroxyguanine (oh8Gua), which
is an oxidatively damaged mutagenic base. To clarify whether the DNA repair activity of …

An increasing number of studies indicate that reduced DNA-repair capacity is associated
with increased cancer risk. Using a functional assay for the removal of the oxidative DNA …