5-chloro-2-guanidinobenzimidazole (ClGBI), a small-molecule guanidine derivative, is a
known effective inhibitor of the voltage-gated proton (H+) channel (HV1, Kd≈ 26 μM) and is …

The human voltage-gated proton channel (hH V 1) has a main role in the regulation of
intracellular pH, preventing acidosis. Furthermore, hH V 1 has been shown to play role in the …

The voltage-gated proton channel Hv1 plays important roles in proton extrusion, pH
homeostasis, and production of reactive oxygen species in a variety of cell types. Excessive …

The voltage-gated hydrogen channel Hv1 encoded in humans by the HVCN1 gene is a
highly selective proton channel that allows large fluxes of protons across biological …

The human voltage-gated proton channel Hv1 is a drug target for cancer, ischemic stroke,
and neuroinflammation. It resides on the plasma membrane and endocytic compartments of …

Voltage‐gated proton channels (HV1) have been found in many mammalian cells and play
a crucial role in the immune system, male fertility, and cancer progression …

The human voltage-gated proton channel, hHV1, is highly expressed in various cell types
including macrophages, B lymphocytes, microglia, sperm cells and also in various cancer …

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, expressed in a variety
of cell types and in all tissues, control excitation and rhythm. Since their discovery in neurons …

Of the∼ 22,000 protein-coding genes in the human genome, an estimated 8,000 are
druggable (1). The current drug market targets no more than 450 unique human proteins (1) …

Voltage-gated proton channels (HV) are unique, in part because the ion they conduct is
unique. HV channels are perfectly selective for protons and have a very small unitary …