The presence of multidrug resistance (MDR) in malignant tumors is one of the primary
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …

Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer
chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP …

This year marks the 30th anniversary of the discovery of the multidrug resistance (MDR) ATP-
binding cassette (ABC) transporter P-glycoprotein (P-gp). Since then a considerable …

One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR),
where cancer cells simultaneously become resistant to different anticancer drugs. Over …

The multidrug resistant phenotype of cancer cells can often result from the over-production
of a number of ATP binding cassette (ABC) transporters, including P-glycoprotein (P-gp) …

Many tumor cells become resistant to commonly used cytotoxic drugs due to the
overexpression of ATP-binding cassette (ABC) transporters, namely P-glycoprotein (P-gp) …

P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding
cassette sub-family B member 1 (ABCB1) plays a crucial role in determining response …

Multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy. P-
glycoprotein (P-gp), a promiscuous drug efflux pump, has been extensively studied for its …

During the last decades multidrug resistance (MDR) emerged as main problem in the anti-
cancer therapy with cytostatically active agents. Classical as well as recently developed …

P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The
protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of …