Puberty is a complex biological process of sexual development, influenced by genetic,
metabolic-nutritional, environmental and socioeconomic factors, characterized by the …

The initiation of puberty is a crucial timepoint of development, with its disruptions being
associated with multiple physical and psychological complications. Idiopathic Central …

Background/Aims: Kisspeptin (KISS1)/GPR54 (KISSR) signaling complex and neurokinin B
(NKB)/NKB receptor (TACR3) signaling have been proposed as an integral part of the …

Study Objective The well-known tumor suppressor transcriptional factor p53 has been
proposed to be one of the central hubs of a functionally related and hierarchically arranged …

Gonadotropin releasing hormone (GnRH) neurons play a crucial role in the development
and functioning of the hypothalamus-pituitary-gonadal (HPG) axis, ultimately acting as the …

Background: Central Precocious Puberty (CPP) is clinically defined by the development of
secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. To …

Background: Central precocious puberty (CPP) is one of the most common and complex
problems in clinical pediatric endocrinology practice. Mutation of the MKRN3 gene can …

Human puberty is a complex, coordinated biological process with multiple levels of
regulations. The timing of puberty varies greatly in children and is influenced by both …

Puberty is a major developmental stage. Damaging mutations, considered as “mistakes of
nature”, have contributed to the unraveling of the networks implicated in the normal initiation …

Background Pubertal timing is known to be influenced by interactions among various
genetic, nutritional, environmental and socio-economic factors, although the ultimate …