Aims/hypothesis Glucagon-expressing pancreatic alpha cells have attracted much attention
for their plasticity to transdifferentiate into insulin-producing beta cells; however, it remains …

Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine
progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and …

Diabetes is a chronic and incurable disease, which results from absolute or relative insulin
insufficiency. Therefore, pancreatic beta cells, which are the only type of cell that expresses …

Although numerous studies have uncovered the molecular mechanisms regulating
pancreas development, it remains to be clarified how β-cells arise from progenitors and how …

Pancreatic β and α cells play essential roles in maintaining glucose homeostasis. However,
the mechanisms by which these distinct cell populations are generated, expand, and mature …

Newly differentiated pancreatic β cells lack proper insulin secretion profiles of mature
functional β cells. The global gene expression differences between paired immature and …

Research on the postnatal development of pancreatic beta-cells has become an important
subject in recent years. Understanding the mechanisms that govern beta-cell postnatal …

Alpha and beta cells act in concert to maintain blood glucose. Alpha cells release glucagon
in response to low glucose to stimulate glycogenolysis in the liver. In contrast, beta cells …

Understanding the origins of insulin-producing beta cells of the pancreas could lead to new
treatments for diabetes. Collombat et al.(2009) now show that in response to injury, a …

In comparison to mouse, the developmental process of human islets has not been properly
elucidated. The advancement of single cell RNA-seq technology enables us to study the …