Although the functional properties of ion channels are most accurately assessed using
electrophysiological approaches, a number of experimental situations call for alternative …

The surprising difficulty of “simple” equilibrium binding measurements on ligand-gated ion
channels | Journal of General Physiology | Rockefeller University Press Skip to Main Content …

Ligand-gated ion channels are formed by three to five subunits that control the opening of
the pore in a cooperative fashion. We developed a microfluidic chip-based technique for …

Ion channels are pore-forming membrane proteins which enable the rapid passage (flux) of
ions across cell membranes. Their ion conductivity is often highly specific and has been …

Publisher Summary This chapter discusses ligand-gated ion channels, which are membrane
proteins that are fundamental signaling molecules in neurons. The chapter is divided into …

Ligand-gated ion channels are chemosensors that convert chemical signals into electrical
signals. They are a diverse set of multimeric allosteric proteins where the binding of ligand …

Ligand-gated ion channels (LGICs) are fast-responding channels in which the receptor,
which binds the activating molecule (the ligand), and the ion channel are part of the same …

Anion/cation selectivity is a critical property of ion channels and underpins their
physiological function. Recently, there have been numerous mutagenesis studies, which …

Ligand-gated ion channels are integral glycoproteins that transverse the cell membrane. All
molecularly characterized ligand-gated ion channels are multisubunit complexes. Ligand …

Ligand-and voltage-gated ion channels form a large superfamily of membranebound
signalling proteins that fulfil many important roles in health and disease (Hille, 2001) …